Showing entry for E3 ubiquitin-protein ligase parkin



                       
General Target Information
BXGT IdBXGT020828
Protein NameE3 ubiquitin-protein ligase parkin
Uniport IdQ9JK66
GenePrkn
Gene Id56816
DomainIBR; ubiquitin; zf-RING_12; zf-RING_14
Pfam PF01485   PF00240   PF17976   PF17978  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008344 adult locomotory behavior
Biological Process GO:0070842 aggresome assembly
Biological Process GO:0000422 autophagy of mitochondrion
Biological Process GO:0007420 brain development
Biological Process GO:0044257 cellular protein catabolic process
Biological Process GO:1904881 cellular response to hydrogen sulfide
Biological Process GO:1905232 cellular response to L-glutamate
Biological Process GO:1904845 cellular response to L-glutamine
Biological Process GO:0071287 cellular response to manganese ion
Biological Process GO:0097237 cellular response to toxic substance
Biological Process GO:0042417 dopamine metabolic process
Biological Process GO:0051583 dopamine uptake involved in synaptic transmission
Biological Process GO:0010994 free ubiquitin chain polymerization
Biological Process GO:0007612 learning
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0000266 mitochondrial fission
Biological Process GO:0043653 mitochondrial fragmentation involved in apoptotic process
Biological Process GO:0051646 mitochondrion localization
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0099074 mitochondrion to lysosome transport
Biological Process GO:0000423 mitophagy
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0044828 negative regulation by host of viral genome replication
Biological Process GO:0032232 negative regulation of actin filament bundle assembly
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Biological Process GO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
Biological Process GO:0090394 negative regulation of excitatory postsynaptic potential
Biological Process GO:1903542 negative regulation of exosomal secretion
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0033132 negative regulation of glucokinase activity
Biological Process GO:0046676 negative regulation of insulin secretion
Biological Process GO:1905366 negative regulation of intralumenal vesicle formation
Biological Process GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process GO:0046329 negative regulation of JNK cascade
Biological Process GO:0090258 negative regulation of mitochondrial fission
Biological Process GO:0010637 negative regulation of mitochondrial fusion
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:1903204 negative regulation of oxidative stress-induced neuron death
Biological Process GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
Biological Process GO:1902283 negative regulation of primary amine oxidase activity
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:1903427 negative regulation of reactive oxygen species biosynthetic process
Biological Process GO:2000378 negative regulation of reactive oxygen species metabolic process
Biological Process GO:0090201 negative regulation of release of cytochrome c from mitochondria
Biological Process GO:1904049 negative regulation of spontaneous neurotransmitter secretion
Biological Process GO:0051967 negative regulation of synaptic transmission, glutamatergic
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0070050 neuron cellular homeostasis
Biological Process GO:0042415 norepinephrine metabolic process
Biological Process GO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:2001171 positive regulation of ATP biosynthetic process
Biological Process GO:1903599 positive regulation of autophagy of mitochondrion
Biological Process GO:1903861 positive regulation of dendrite extension
Biological Process GO:0043388 positive regulation of DNA binding
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0090141 positive regulation of mitochondrial fission
Biological Process GO:0010636 positive regulation of mitochondrial fusion
Biological Process GO:0010918 positive regulation of mitochondrial membrane potential
Biological Process GO:1901526 positive regulation of mitophagy
Biological Process GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization
Biological Process GO:0051582 positive regulation of neurotransmitter uptake
Biological Process GO:1901800 positive regulation of proteasomal protein catabolic process
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:1902530 positive regulation of protein linear polyubiquitination
Biological Process GO:1905477 positive regulation of protein localization to membrane
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0051865 protein autoubiquitination
Biological Process GO:0031648 protein destabilization
Biological Process GO:0070979 protein K11-linked ubiquitination
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0070534 protein K63-linked ubiquitination
Biological Process GO:0085020 protein K6-linked ubiquitination
Biological Process GO:0070585 protein localization to mitochondrion
Biological Process GO:0019538 protein metabolic process
Biological Process GO:0006513 protein monoubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0050821 protein stabilization
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0010506 regulation of autophagy
Biological Process GO:1900407 regulation of cellular response to oxidative stress
Biological Process GO:0042053 regulation of dopamine metabolic process
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0051881 regulation of mitochondrial membrane potential
Biological Process GO:0010821 regulation of mitochondrion organization
Biological Process GO:0046928 regulation of neurotransmitter secretion
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0031396 regulation of protein ubiquitination
Biological Process GO:2000377 regulation of reactive oxygen species metabolic process
Biological Process GO:0051412 response to corticosterone
Biological Process GO:1904643 response to curcumin
Biological Process GO:0042493 response to drug
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:0014850 response to muscle activity
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0006986 response to unfolded protein
Biological Process GO:0001964 startle response
Biological Process GO:0001963 synaptic transmission, dopaminergic
Biological Process GO:0035249 synaptic transmission, glutamatergic
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
Biological Process GO:0055069 zinc ion homeostasis
molecular function GO:0003779 actin binding
molecular function GO:0008013 beta-catenin binding
molecular function GO:0051087 chaperone binding
molecular function GO:0097602 cullin family protein binding
molecular function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
molecular function GO:0019899 enzyme binding
molecular function GO:1990444 F-box domain binding
molecular function GO:0001664 G protein-coupled receptor binding
molecular function GO:0031072 heat shock protein binding
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0030544 Hsp70 protein binding
molecular function GO:0042802 identical protein binding
molecular function GO:0019900 kinase binding
molecular function GO:0046872 metal ion binding
molecular function GO:0030165 PDZ domain binding
molecular function GO:0043274 phospholipase binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
molecular function GO:0015631 tubulin binding
molecular function GO:0043130 ubiquitin binding
molecular function GO:0031624 ubiquitin conjugating enzyme binding
molecular function GO:0061630 ubiquitin protein ligase activity
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0004842 ubiquitin-protein transferase activity
molecular function GO:1990381 ubiquitin-specific protease binding
cellular component GO:0016235 aggresome
cellular component GO:0030424 axon
cellular component GO:0005737 cytoplasm
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0000139 Golgi membrane
cellular component GO:0097708 intracellular vesicle
cellular component GO:0045121 membrane raft
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0005634 nucleus
cellular component GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0014069 postsynaptic density
cellular component GO:0098793 presynapse
cellular component GO:0032991 protein-containing complex
cellular component GO:0045202 synapse
cellular component GO:0008021 synaptic vesicle
cellular component GO:0030672 synaptic vesicle membrane
cellular component GO:0043195 terminal bouton
cellular component GO:0000151 ubiquitin ligase complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein