Showing entry for Sphingosine kinase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021183
Protein NameSphingosine kinase 2
Uniport IdQ9NRA0
GeneSPHK2
Gene Id56848
DomainDAGK_cat
Pfam PF00781  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00600 Sphingolipid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04071 Sphingolipid signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04370 VEGF signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
5. Organismal Systems 5.1 Immune system hsa04666 Fc gamma R-mediated phagocytosis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05152 Tuberculosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001568 blood vessel development
Biological Process GO:0007420 brain development
Biological Process GO:1904628 cellular response to phorbol 13-acetate 12-myristate
Biological Process GO:0002374 cytokine secretion involved in immune response
Biological Process GO:0007565 female pregnancy
Biological Process GO:0043977 histone H2A-K5 acetylation
Biological Process GO:0043980 histone H2B-K12 acetylation
Biological Process GO:0032616 interleukin-13 production
Biological Process GO:0032635 interleukin-6 production
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:1901726 negative regulation of histone deacetylase activity
Biological Process GO:0031064 negative regulation of histone deacetylation
Biological Process GO:0016310 phosphorylation
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0090280 positive regulation of calcium ion import
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:2000304 positive regulation of ceramide biosynthetic process
Biological Process GO:0045815 positive regulation of gene expression, epigenetic
Biological Process GO:2000617 positive regulation of histone H3-K9 acetylation
Biological Process GO:0033008 positive regulation of mast cell activation involved in immune response
Biological Process GO:0043306 positive regulation of mast cell degranulation
Biological Process GO:0090037 positive regulation of protein kinase C signaling
Biological Process GO:2001169 regulation of ATP biosynthetic process
Biological Process GO:1904959 regulation of cytochrome-c oxidase activity
Biological Process GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:1903426 regulation of reactive oxygen species biosynthetic process
Biological Process GO:0006669 sphinganine-1-phosphate biosynthetic process
Biological Process GO:0030148 sphingolipid biosynthetic process
Biological Process GO:0006665 sphingolipid metabolic process
Biological Process GO:0046512 sphingosine biosynthetic process
Biological Process GO:0006670 sphingosine metabolic process
Biological Process GO:1990774 tumor necrosis factor secretion
molecular function GO:0005524 ATP binding
molecular function GO:0017050 D-erythro-sphingosine kinase activity
molecular function GO:0001727 lipid kinase activity
molecular function GO:0003951 NAD+ kinase activity
molecular function GO:0031493 nucleosomal histone binding
molecular function GO:0017016 Ras GTPase binding
molecular function GO:0008481 sphinganine kinase activity
molecular function GO:0038036 sphingosine-1-phosphate receptor activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005765 lysosomal membrane
cellular component GO:0016020 membrane
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0000786 nucleosome
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1660661 Sphingolipid de novo biosynthesis
R-HSA-428157 Sphingolipid metabolism
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008055 BXGD000514 Chikungunya Fever Infections
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011311 BXGD000714 Dengue Fever Infections
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0023891 BXGD001714 Liver Cirrhosis, Alcoholic Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Chemically-Induced Disorders
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023896 BXGD001718 Alcoholic Liver Diseases Digestive System Diseases; Chemically-Induced Disorders
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0025261 BXGD001843 Memory Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039103 BXGD002791 Synovitis Musculoskeletal Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0041956 BXGD002942 Ureteral obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0221269 BXGD004429 Pseudolymphoma Hemic and Lymphatic Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235272 BXGD004737 Retinal damage Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases; Wounds and Injuries
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238281 BXGD004902 Middle Cerebral Artery Syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0238339 BXGD004914 Hereditary pancreatitis Digestive System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243038 BXGD005211 Carcinoma, Lewis Lung Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0432283 BXGD008764 Osteoglophonic dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740376 BXGD009982 Middle Cerebral Artery Thrombosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0740392 BXGD009988 Infarction, Middle Cerebral Artery Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751292 BXGD010380 Age-Related Memory Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751293 BXGD010381 Memory Disorder, Semantic Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751294 BXGD010382 Memory Disorder, Spatial Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751295 BXGD010383 Memory Loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0751845 BXGD010605 Middle Cerebral Artery Embolus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751846 BXGD010606 Left Middle Cerebral Artery Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751847 BXGD010607 Embolic Infarction, Middle Cerebral Artery Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751848 BXGD010608 Thrombotic Infarction, Middle Cerebral Artery Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751849 BXGD010609 Right Middle Cerebral Artery Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1292753 BXGD012226 Primary Effusion Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1519689 BXGD013245 Tumor Promotion Pathological Conditions, Signs and Symptoms; Neoplasms
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2062441 BXGD016897 Influenza A
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4554344 BXGD023564 IgE-mediated food allergy Immune System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003364 Cerebroside 299.49
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein