protein

General Target Information
BXGT Id	BXGT021204
Protein Name	Sodium- and chloride-dependent GABA transporter 2
Uniport Id	Q9NSD5
Gene	SLC6A13
Gene Id	6540
Domain	SNF
Pfam	PF00209
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0089718	amino acid import across plasma membrane
Biological Process	GO:0015881	creatine transmembrane transport
Biological Process	GO:0051939	gamma-aminobutyric acid import
Biological Process	GO:0015718	monocarboxylic acid transport
Biological Process	GO:0006836	neurotransmitter transport
Biological Process	GO:0071705	nitrogen compound transport
Biological Process	GO:0010940	positive regulation of necrotic cell death
Biological Process	GO:0015734	taurine transport
Biological Process	GO:0150104	transport across blood-brain barrier
molecular function	GO:0015171	amino acid transmembrane transporter activity
molecular function	GO:0005308	creatine transmembrane transporter activity
molecular function	GO:0005332	gamma-aminobutyric acid:sodium symporter activity
molecular function	GO:0015185	gamma-aminobutyric acid transmembrane transporter activity
molecular function	GO:0008028	monocarboxylic acid transmembrane transporter activity
molecular function	GO:0042165	neurotransmitter binding
molecular function	GO:0005368	taurine transmembrane transporter activity
cellular component	GO:0016323	basolateral plasma membrane
cellular component	GO:0070062	extracellular exosome
cellular component	GO:0005887	integral component of plasma membrane
cellular component	GO:0043005	neuron projection
cellular component	GO:0005886	plasma membrane

Reactome

Pathway Id	Pathway Name
R-HSA-112310	Neurotransmitter release cycle
R-HSA-112315	Transmission across Chemical Synapses
R-HSA-112316	Neuronal System
R-HSA-382551	Transport of small molecules
R-HSA-425366	Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407	SLC-mediated transmembrane transport
R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters
R-HSA-888590	GABA synthesis, release, reuptake and degradation
R-HSA-888593	Reuptake of GABA

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0004623	BXGD000282	Bacterial Infections	Infections
C0005586	BXGD000315	Bipolar Disorder	Mental Disorders
C0007786	BXGD000486	Brain Ischemia	Nervous System Diseases; Cardiovascular Diseases
C0014070	BXGD000887	Encephalomyelitis	Infections; Nervous System Diseases
C0014544	BXGD000926	Epilepsy	Nervous System Diseases
C0017654	BXGD001136	Glomerular Filtration Rate
C0022661	BXGD001572	Kidney Failure, Chronic	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0038454	BXGD002760	Cerebrovascular accident	Nervous System Diseases; Cardiovascular Diseases
C0041696	BXGD002932	Unipolar Depression	Mental Disorders
C0085648	BXGD003221	Synovial Cyst	Neoplasms
C0201976	BXGD004063	Creatinine measurement, serum (procedure)
C0338656	BXGD007211	Impaired cognition	Mental Disorders
C0523465	BXGD009209	Serum albumin measurement
C0948008	BXGD011499	Ischemic stroke	Nervous System Diseases; Cardiovascular Diseases
C1258666	BXGD011825	Myxoid cyst	Neoplasms; Skin and Connective Tissue Diseases
C1269683	BXGD012001	Major Depressive Disorder	Mental Disorders
C1272352	BXGD012013	Deficiency of vitamin D3	Nutritional and Metabolic Diseases
C1384666	BXGD012948	hearing impairment	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1561643	BXGD013363	Chronic Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases

Target protein-related compounds

Compounds

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}