Showing entry for NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021242
Protein NameNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Uniport IdQ9NX14
GeneNDUFB11
Gene Id54539
DomainESSS
Pfam PF10183  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.2 Energy metabolism hsa00190 Oxidative phosphorylation
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04932 Non-alcoholic fatty liver disease (NAFLD)
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
6. Human Diseases 6.4 Neurodegenerative diseases hsa05012 Parkinson disease
6. Human Diseases 6.4 Neurodegenerative diseases hsa05016 Huntington disease
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006120 mitochondrial electron transport, NADH to ubiquinone
Biological Process GO:0032981 mitochondrial respiratory chain complex I assembly
cellular component GO:0016021 integral component of membrane
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005747 mitochondrial respiratory chain complex I
Reactome
Pathway Id Pathway Name
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728 Metabolism
R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
R-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001125 BXGD000024 Acidosis, Lactic Nutritional and Metabolic Diseases
C0002418 BXGD000112 Amblyopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0002896 BXGD000153 Sideroblastic anemia Hemic and Lymphatic Diseases
C0003119 BXGD000177 Anophthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0003466 BXGD000193 Anus, Imperforate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0003537 BXGD000208 Aphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013528 BXGD000851 Echolalia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014588 BXGD000937 Epispadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015930 BXGD001025 Fetal Distress Pathological Conditions, Signs and Symptoms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018816 BXGD001234 Heart Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0023380 BXGD001640 Lethargy Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026266 BXGD001895 Mitral Valve Insufficiency Cardiovascular Diseases
C0026267 BXGD001896 Mitral Valve Prolapse Syndrome Cardiovascular Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026884 BXGD001945 Mutism Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0027092 BXGD001971 Myopia Eye Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029132 BXGD002117 Disorder of the optic nerve Eye Diseases; Nervous System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0035313 BXGD002532 Retinal Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0040961 BXGD002891 Tricuspid Valve Insufficiency Cardiovascular Diseases
C0040962 BXGD002892 Tricuspid Valve Prolapse Cardiovascular Diseases
C0041834 BXGD002935 Erythema Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151514 BXGD003429 Atrophic condition of skin Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0156394 BXGD003856 Hypertrophy of clitoris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0162666 BXGD003967 Mitochondrial Encephalomyopathies Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0162670 BXGD003970 Mitochondrial Myopathies Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0162834 BXGD003988 Hyperpigmentation Skin and Connective Tissue Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0220981 BXGD004348 Metabolic acidosis Nutritional and Metabolic Diseases
C0221182 BXGD004401 Chordee Male Urogenital Diseases
C0232466 BXGD004543 Feeding difficulties
C0235812 BXGD004770 Vitritis Pathological Conditions, Signs and Symptoms; Infections; Eye Diseases; Nervous System Diseases
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0238395 BXGD004922 Male Pseudohermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0240063 BXGD005015 Coloboma of iris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0265886 BXGD005585 Overriding aorta Respiratory Tract Diseases; Cardiovascular Diseases
C0266210 BXGD005631 Congenital anomaly of rectum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0266361 BXGD005656 True Hermaphroditism (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0266362 BXGD005657 Ambiguous Genitalia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0266399 BXGD005663 Infantile uterus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0266551 BXGD005693 Congenital coloboma of iris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0281842 BXGD006787 Abnormality of the fallopian tube
C0342776 BXGD007546 Nicotinamide adenine dinucleotide coenzyme Q reductase deficiency
C0344511 BXGD007682 Atresia of nasolacrimal duct Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0349588 BXGD007933 Short stature
C0410916 BXGD008452 Neonatal Death Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0424503 BXGD008532 Dysmorphic facies
C0426421 BXGD008561 Wide nose
C0426848 BXGD008590 Sacral dimple Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0431371 BXGD008676 Absence of septum pellucidum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0431384 BXGD008681 Colpocephaly Nervous System Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0546967 BXGD009349 Posterior embryotoxon Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0554970 BXGD009428 Pallor of optic disc
C0557874 BXGD009444 Global developmental delay
C0581342 BXGD009560 Redundant skin Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0685776 BXGD009816 Congenital absence of mandible
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C0796070 BXGD010792 MICROPHTHALMIA, SYNDROMIC 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0853087 BXGD010964 Nail abnormality Pathological Conditions, Signs and Symptoms
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C0917796 BXGD011408 Optic Atrophy, Hereditary, Leber Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0973461 BXGD011595 Dysphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1167918 BXGD011779 Increased CSF lactate
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1445953 BXGD013080 Poor eye contact Mental Disorders
C1708371 BXGD013600 Histiocytoid Cardiomyopathy Cardiovascular Diseases
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836735 BXGD014155 hypopigmented skin patch Skin and Connective Tissue Diseases
C1838705 BXGD014341 Anteriorly placed anus
C1838979 BXGD014349 MITOCHONDRIAL COMPLEX I DEFICIENCY Nutritional and Metabolic Diseases
C1839603 BXGD014388 Proximal tubulopathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1847515 BXGD014869 Paroxysmal involuntary eye movements
C1847879 BXGD014895 X-linked dominant inheritance
C1849367 BXGD015046 Nasal bridge wide
C1849488 BXGD015058 Increased serum pyruvate
C1853235 BXGD015318 Sclerocornea Eye Diseases
C1853242 BXGD015322 Midface retrusion
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1856409 BXGD015604 Dilation of lateral ventricles
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1866245 BXGD016390 Hyperpigmented streaks
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2675111 BXGD017272 Abnormal eyelash morphology
C2677650 BXGD017382 Decreased activity of mitochondrial complex I
C2919142 BXGD017867 Short Stature, CTCAE
C3494422 BXGD018966 Retrognathia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386 BXGD019284 Abnormal vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021546 BXGD020663 Abnormal mitochondria in muscle tissue
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4021800 BXGD020790 Abnormality of dental enamel
C4022748 BXGD020979 Focal T2 hyperintense brainstem lesion
C4023440 BXGD021187 Cleft earlobe
C4024809 BXGD021425 Chorioretinal dysplasia
C4024888 BXGD021457 Asymmetric, linear skin defects
C4025329 BXGD021647 Abnormality of the anus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4025360 BXGD021652 Functional motor deficit
C4025790 BXGD021791 Specific learning disability
C4025835 BXGD021819 Abnormal nasolacrimal system morphology
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4225421 BXGD022274 LINEAR SKIN DEFECTS WITH MULTIPLE CONGENITAL ANOMALIES 3
C4551490 BXGD023316 Ovotestis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C4551511 BXGD023330 X-linked sideroblastic anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4746985 BXGD023966 MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 30
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005989 Auraptene 298.38
BXGC0014139 R-(+)-Marmin 332.16
BXGC0015383 7-(6'r-Hydroxy-3',7'-Dimethyl-2'e,7'-Octadienyloxy)Coumarin 314.15
BXGC0031377 7-[(E,6R)-7-Chloro-6-Hydroxy-3,7-Dimethyloct-2-Enoxy]Chromen-2-One 350.13
BXGC0032047 7-[(2E)-3,7-Dimethylocta-2,6-Dienoxy]-6-Methoxychromen-2-One 328.17
BXGC0035162 Dehydromarmeline 335.19
BXGC0037648 (+)-9'-Isovaleroxylariciresinol 444.21
BXGC0039815 7-[(E,6R)-6-Hydroxy-7-Methoxy-3,7-Dimethyloct-2-Enoxy]Chromen-2-One 346.18
BXGC0045118 R-(+)-Marmin-6'-Octanoate 458.27
BXGC0045119 R-(+)-Marmin-6'-Undecanoate 500.31
BXGC0045120 R-(+)-Marmin-6'-palmitate 570.39
BXGC0045121 R-(+)-Marmin-6'-Linoleate 594.39
BXGC0045122 R-(+)-Marmin-6'-cis-vaccenoate 596.41
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein