Showing entry for Group IIE secretory phospholipase A2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021276
Protein NameGroup IIE secretory phospholipase A2
Uniport IdQ9NZK7
GenePLA2G2E
Gene Id30814
DomainPhospholip_A2_1
Pfam PF00068  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00564 Glycerophospholipid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00565 Ether lipid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00591 Linoleic acid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00592 alpha-Linolenic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
5. Organismal Systems 5.4 Digestive system hsa04975 Fat digestion and absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0050482 arachidonic acid secretion
Biological Process GO:0006954 inflammatory response
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0034374 low-density lipoprotein particle remodeling
Biological Process GO:0006654 phosphatidic acid biosynthetic process
Biological Process GO:0036151 phosphatidylcholine acyl-chain remodeling
Biological Process GO:0036152 phosphatidylethanolamine acyl-chain remodeling
Biological Process GO:0036148 phosphatidylglycerol acyl-chain remodeling
Biological Process GO:0036149 phosphatidylinositol acyl-chain remodeling
Biological Process GO:0036150 phosphatidylserine acyl-chain remodeling
Biological Process GO:0006644 phospholipid metabolic process
molecular function GO:0047498 calcium-dependent phospholipase A2 activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0004623 phospholipase A2 activity
molecular function GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
molecular function GO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
molecular function GO:0005543 phospholipid binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005576 extracellular region
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA
R-HSA-1483206 Glycerophospholipid biosynthesis
R-HSA-1483257 Phospholipid metabolism
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0024897 BXGD001811 Mastocytoma Neoplasms; Skin and Connective Tissue Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0334664 BXGD007150 Mast Cell Neoplasm Neoplasms
C2242987 BXGD017007 Benign Mastocytoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000557 1H-Indole-3-acetic acid 175.18
BXGC0000565 1H-Indole-3-propanoic acid 189.21
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
BXGC0004666 Anisic acid 152.15
BXGC0004703 Tridecanoic acid 214.34
BXGC0032834 2-[4-[(2R)-2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Phenyl]Acetamide 266.16
BXGC0040462 Aminosalicylic Acid 153.04
BXGC0052675 7-Hydroxy Aristolochic A 357.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein