Showing entry for Potassium voltage-gated channel subfamily D member 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021283
Protein NamePotassium voltage-gated channel subfamily D member 2
Uniport IdQ9NZV8
GeneKCND2
Gene Id3751
DomainBTB_2; DUF3399; Ion_trans; Shal-type
Pfam PF02214   PF11879   PF00520   PF11601  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001508 action potential
Biological Process GO:0061337 cardiac conduction
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0045475 locomotor rhythm
Biological Process GO:0019228 neuronal action potential
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0034765 regulation of ion transmembrane transport
Biological Process GO:0019233 sensory perception of pain
molecular function GO:0005250 A-type (transient outward) potassium channel activity
molecular function GO:0046872 metal ion binding
molecular function GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
molecular function GO:0005249 voltage-gated potassium channel activity
cellular component GO:0043197 dendritic spine
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099055 integral component of postsynaptic membrane
cellular component GO:0031226 intrinsic component of plasma membrane
cellular component GO:0032809 neuronal cell body membrane
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
cellular component GO:0044853 plasma membrane raft
cellular component GO:0014069 postsynaptic density
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0008076 voltage-gated potassium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-1296071 Potassium Channels
R-HSA-1296072 Voltage gated Potassium channels
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235480 BXGD004751 Paroxysmal atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0276138 BXGD006403 Viral myocarditis Infections; Cardiovascular Diseases
C0312422 BXGD006888 Blackout - symptom Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700178 BXGD009876 Alcoholic blackout Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1142166 BXGD011736 Brugada Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1720824 BXGD013686 Sudden Cardiac Arrest Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0047867 Dalfampridine 94.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein