Showing entry for Core histone macro-H2A.2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021290
Protein NameCore histone macro-H2A.2
Uniport IdQ9P0M6
GeneMACROH2A2
Gene Id55506
DomainHistone; Histone_H2A_C; Macro
Pfam PF00125   PF16211   PF01661  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04217 Necroptosis
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007420 brain development
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006342 chromatin silencing
Biological Process GO:0007549 dosage compensation
Biological Process GO:0071169 establishment of protein localization to chromatin
Biological Process GO:0045814 negative regulation of gene expression, epigenetic
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:1901837 negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:0045618 positive regulation of keratinocyte differentiation
molecular function GO:0031490 chromatin DNA binding
molecular function GO:0003677 DNA binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
cellular component GO:0001740 Barr body
cellular component GO:0070062 extracellular exosome
cellular component GO:0000790 nuclear chromatin
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0005654 nucleoplasm
cellular component GO:0000786 nucleosome
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003463 BXGD000192 Anus Neoplasms Digestive System Diseases; Neoplasms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0347129 BXGD007848 Dysplasia of anus Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0349534 BXGD007919 Carcinoma of anal margin Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1412036 BXGD013053 Anal squamous cell carcinoma Digestive System Diseases; Neoplasms
C2349568 BXGD017062 Anal intraepithelial neoplasia I and II (AIN I and II) (histologically confirmed)
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein