Showing entry for Poly [ADP-ribose] polymerase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021688
Protein NamePoly [ADP-ribose] polymerase 2
Uniport IdQ9UGN5
GenePARP2
Gene Id10038
DomainPARP; PARP_reg; WGR
Pfam PF00644   PF02877   PF05406  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03410 Base excision repair
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
4. Cellular Processes 4.2 Cell growth and death hsa04217 Necroptosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006284 base-excision repair
Biological Process GO:0030592 DNA ADP-ribosylation
Biological Process GO:0006281 DNA repair
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0097191 extrinsic apoptotic signaling pathway
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:0018312 peptidyl-serine ADP-ribosylation
Biological Process GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
Biological Process GO:0006471 protein ADP-ribosylation
Biological Process GO:0070212 protein poly-ADP-ribosylation
molecular function GO:0003677 DNA binding
molecular function GO:0003950 NAD+ ADP-ribosyltransferase activity
molecular function GO:0140294 NAD DNA ADP-ribosyltransferase activity
molecular function GO:1990404 protein ADP-ribosylase activity
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
R-HSA-5685939 HDR through MMEJ (alt-NHEJ)
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693538 Homology Directed Repair
R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696398 Nucleotide Excision Repair
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-73884 Base Excision Repair
R-HSA-73894 DNA Repair
R-HSA-73933 Resolution of Abasic Sites (AP sites)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0235950 BXGD004790 Zinc deficiency Nutritional and Metabolic Diseases
C0278689 BXGD006563 Recurrent ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1514428 BXGD013203 Primary peritoneal carcinoma Digestive System Diseases; Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0018736 Benzamide 121.05
BXGC0038633 3-Methoxycinnamic acid 178.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein