Showing entry for DNA polymerase lambda


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021689
Protein NameDNA polymerase lambda
Uniport IdQ9UGP5
GenePOLL
Gene Id27343
DomainDNA_pol_B_palm; DNA_pol_B_thumb; DNA_pol_lambd_f; HHH_8
Pfam PF14792   PF14791   PF10391   PF14716  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03410 Base excision repair
2. Genetic Information Processing 2.4 Replication and repair hsa03450 Non-homologous end-joining
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006287 base-excision repair, gap-filling
Biological Process GO:0071897 DNA biosynthetic process
Biological Process GO:0006260 DNA replication
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:0006303 double-strand break repair via nonhomologous end joining
Biological Process GO:0006289 nucleotide-excision repair
Biological Process GO:0016446 somatic hypermutation of immunoglobulin genes
molecular function GO:0051575 5'-deoxyribose-5-phosphate lyase activity
molecular function GO:0003677 DNA binding
molecular function GO:0003887 DNA-directed DNA polymerase activity
molecular function GO:0046872 metal ion binding
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-73894 DNA Repair
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0008780 BXGD000571 Ciliary Motility Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0043119 BXGD003029 Werner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4551720 BXGD023400 Primary Ciliary Dyskinesia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0001991 Juglone 174.15
BXGC0002187 Octadecanoic acid 284.48
BXGC0002244 Doconexent 328.49
BXGC0002248 Dodecanoic acid 200.32
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0002803 Sedanoic acid 116.16
BXGC0003627 alpha-Linoleic acid 280.45
BXGC0003705 Chloride 35.45
BXGC0004269 Propanoic acid 74.08
BXGC0004277 Acetic acid 60.05
BXGC0006107 alpha-Linolenic acid 278.43
BXGC0006198 Citric acid 192.12
BXGC0014782 Icosapent 302.22
BXGC0020201 Oblongifolin C 670.42
BXGC0034894 Oleic Acid 282.26
BXGC0043955 Guttiferone K 602.36
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein