Showing entry for Mitotic spindle assembly checkpoint protein MAD2B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021714
Protein NameMitotic spindle assembly checkpoint protein MAD2B
Uniport IdQ9UI95
GeneMAD2L2
Gene Id10459
DomainHORMA
Pfam PF02301  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04110 Cell cycle
4. Cellular Processes 4.2 Cell growth and death hsa04114 Oocyte meiosis
5. Organismal Systems 5.2 Endocrine system hsa04914 Progesterone-mediated oocyte maturation
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05100 Bacterial invasion of epithelial cells
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05131 Shigellosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007015 actin filament organization
Biological Process GO:0051301 cell division
Biological Process GO:0042772 DNA damage response, signal transduction resulting in transcription
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0042276 error-prone translesion synthesis
Biological Process GO:0007094 mitotic spindle assembly checkpoint
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:2000042 negative regulation of double-strand break repair via homologous recombination
Biological Process GO:0010719 negative regulation of epithelial to mesenchymal transition
Biological Process GO:0042177 negative regulation of protein catabolic process
Biological Process GO:0010944 negative regulation of transcription by competitive promoter binding
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:2000678 negative regulation of transcription regulatory region DNA binding
Biological Process GO:1904667 negative regulation of ubiquitin protein ligase activity
Biological Process GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining
Biological Process GO:0045830 positive regulation of isotype switching
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0001558 regulation of cell growth
molecular function GO:0008432 JUN kinase binding
molecular function GO:0001102 RNA polymerase II activating transcription factor binding
cellular component GO:0005694 chromosome
cellular component GO:0005829 cytosol
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0035861 site of double-strand break
cellular component GO:0005819 spindle
cellular component GO:0016035 zeta DNA polymerase complex
Reactome
Pathway Id Pathway Name
R-HSA-110312 Translesion synthesis by REV1
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
R-HSA-5655862 Translesion synthesis by POLK
R-HSA-5656121 Translesion synthesis by POLI
R-HSA-73893 DNA Damage Bypass
R-HSA-73894 DNA Repair
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003466 BXGD000193 Anus, Imperforate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0003857 BXGD000228 Congenital arteriovenous malformation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0004106 BXGD000254 Astigmatism Eye Diseases
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0008297 BXGD000522 Choanal Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013371 BXGD000823 Shigella Infections Digestive System Diseases; Infections
C0015300 BXGD000973 Exophthalmos Eye Diseases
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0025037 BXGD001822 Meckel Diverticulum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026985 BXGD001956 Myelodysplasia
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0039685 BXGD002825 Tetralogy of Fallot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040588 BXGD002879 Tracheoesophageal Fistula Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Respiratory Tract Diseases
C0041956 BXGD002942 Ureteral obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079924 BXGD003103 Oligohydramnios Female Urogenital Diseases and Pregnancy Complications
C0080178 BXGD003107 Spina Bifida Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151311 BXGD003412 Cranial nerve palsies Nervous System Diseases
C0151640 BXGD003453 Decreased fertility in males Male Urogenital Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0221352 BXGD004444 Syndactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221358 BXGD004450 Long narrow head
C0235971 BXGD004795 Elevated alpha-fetoprotein
C0238093 BXGD004872 Stenosis of duodenum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0241397 BXGD005095 Triphalangeal thumb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0262655 BXGD005264 Recurrent urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0265219 BXGD005468 Miller Dieker syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0265660 BXGD005561 Syndactyly of the toes Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266387 BXGD005661 Bicornuate uterus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0266589 BXGD005698 Congenital ear anomaly NOS (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Otorhinolaryngologic Diseases
C0272027 BXGD006296 Pyridoxine-responsive sideroblastic anemia Hemic and Lymphatic Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0342526 BXGD007495 Absent testes
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376544 BXGD008001 Hematopoietic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0423109 BXGD008470 Upward slant of palpebral fissure
C0423112 BXGD008472 Short palpebral fissure
C0521620 BXGD009150 Dilatation of ureter Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1269955 BXGD012005 Tumor Cell Invasion
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306503 BXGD012363 Congenital exomphalos Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1306710 BXGD012372 Facial asymmetry Pathological Conditions, Signs and Symptoms
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1333295 BXGD012614 Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1836735 BXGD014155 hypopigmented skin patch Skin and Connective Tissue Diseases
C1846460 BXGD014820 Abnormality of the outer ear
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1855710 BXGD015534 Bone marrow hypocellularity
C1857453 BXGD015703 Renal hypoplasia/aplasia
C1857679 BXGD015735 Sloping forehead
C1860236 BXGD015969 Irregular hyperpigmentation Skin and Connective Tissue Diseases
C1860614 BXGD015992 ULNAR HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1861975 BXGD016095 Cafe au lait spots, multiple Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1963099 BXGD016682 Myelodysplasia, CTCAE
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2674432 BXGD017246 Reduced bone mineral density
C2749463 BXGD017620 Aplasia/Hypoplasia of the radius
C2919142 BXGD017867 Short Stature, CTCAE
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3164445 BXGD018529 Abnormality of aortic valve
C3278923 BXGD018748 Dilated ventricles (finding)
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887489 BXGD019879 Clubbing of toes
C4020968 BXGD020516 Abnormal localization of kidney
C4021750 BXGD020755 Abnormality of femur morphology
C4021780 BXGD020775 Abnormality of the liver
C4022016 BXGD020871 Abnormality of the preputium
C4023917 BXGD021276 Aplasia/Hypoplasia of the uvula
C4024748 BXGD021402 Aplasia/Hypoplasia of the iris
C4024780 BXGD021415 Almond-shaped palpebral fissure
C4025071 BXGD021541 Aplasia/Hypoplasia of fingers
C4025211 BXGD021592 Abnormal carotid artery morphology
C4025756 BXGD021778 Abnormal aortic morphology
C4025819 BXGD021808 Abnormality of the hypothalamus-pituitary axis
C4310652 BXGD022612 FANCONI ANEMIA, COMPLEMENTATION GROUP V
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4551705 BXGD023397 Abnormality of chromosome stability
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein