Showing entry for Probable ATP-dependent RNA helicase DDX41


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021731
Protein NameProbable ATP-dependent RNA helicase DDX41
Uniport IdQ9UJV9
GeneDDX41
Gene Id51428
DomainDEAD; Helicase_C
Pfam PF00270   PF00271  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0030154 cell differentiation
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0035458 cellular response to interferon-beta
Biological Process GO:0051607 defense response to virus
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032481 positive regulation of type I interferon production
molecular function GO:0005524 ATP binding
molecular function GO:0003677 DNA binding
molecular function GO:0046872 metal ion binding
molecular function GO:0003723 RNA binding
molecular function GO:0003724 RNA helicase activity
cellular component GO:0071013 catalytic step 2 spliceosome
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0016020 membrane
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-1834941 STING mediated induction of host immune responses
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA
R-HSA-3270619 IRF3-mediated induction of type I IFN
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002893 BXGD000150 Refractory anemias Hemic and Lymphatic Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0018834 BXGD001238 Heartburn Pathological Conditions, Signs and Symptoms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023480 BXGD001664 Leukemia, Myelomonocytic, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026985 BXGD001956 Myelodysplasia
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0036916 BXGD002643 Sexually Transmitted Diseases Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0039128 BXGD002794 Syphilis Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0043154 BXGD003033 Dental White Spot Stomatognathic Diseases
C0085390 BXGD003160 Li-Fraumeni Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases
C0085702 BXGD003247 Monocytosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0262380 BXGD005232 Asymptomatic bacteriuria Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0265219 BXGD005468 Miller Dieker syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0349637 BXGD007942 Common acute lymphoblastic leukemia
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0427543 BXGD008620 Increased blood monocyte number
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0748351 BXGD010194 respiratory compensation
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1611743 BXGD013456 Familial (FPAH)
C1853118 BXGD015302 Severe congenital neutropenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1855710 BXGD015534 Bone marrow hypocellularity
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963099 BXGD016682 Myelodysplasia, CTCAE
C2347761 BXGD017049 Childhood Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C2930974 BXGD017923 Acute erythroleukemia Neoplasms; Hemic and Lymphatic Diseases
C2930975 BXGD017924 Acute erythroleukemia - M6a subtype Neoplasms; Hemic and Lymphatic Diseases
C2930976 BXGD017925 Acute myeloid leukemia FAB-M6 Neoplasms; Hemic and Lymphatic Diseases
C2930977 BXGD017926 Acute erythroleukemia - M6b subtype Neoplasms; Hemic and Lymphatic Diseases
C2939461 BXGD018180 Myeloid neoplasm Neoplasms; Hemic and Lymphatic Diseases
C2987488 BXGD018255 Erythrodysplasia
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3900098 BXGD020106 Adult Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C4225174 BXGD022167 MYELOPROLIFERATIVE/LYMPHOPROLIFERATIVE NEOPLASMS, FAMILIAL (MULTIPLE TYPES), SUSCEPTIBILITY TO
C4733329 BXGD023916 familial acute myeloid leukemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000647 L-Malic acid 134.09
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein