Showing entry for Cytosolic phospholipase A2 gamma


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021795
Protein NameCytosolic phospholipase A2 gamma
Uniport IdQ9UP65
GenePLA2G4C
Gene Id8605
DomainPLA2_B
Pfam PF01735  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00564 Glycerophospholipid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00565 Ether lipid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00591 Linoleic acid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00592 alpha-Linolenic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04217 Necroptosis
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
3. Environmental Information Processing 3.2 Signal transduction hsa04370 VEGF signaling pathway
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.1 Immune system hsa04664 Fc epsilon RI signaling pathway
5. Organismal Systems 5.1 Immune system hsa04666 Fc gamma R-mediated phagocytosis
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
5. Organismal Systems 5.7 Sensory system hsa04750 Inflammatory mediator regulation of TRP channels
5. Organismal Systems 5.2 Endocrine system hsa04912 GnRH signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04913 Ovarian steroidogenesis
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05231 Choline metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019369 arachidonic acid metabolic process
Biological Process GO:0046475 glycerophospholipid catabolic process
Biological Process GO:0006954 inflammatory response
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0140042 lipid droplet formation
Biological Process GO:0007567 parturition
Biological Process GO:0036151 phosphatidylcholine acyl-chain remodeling
Biological Process GO:0036152 phosphatidylethanolamine acyl-chain remodeling
Biological Process GO:0036149 phosphatidylinositol acyl-chain remodeling
Biological Process GO:0006644 phospholipid metabolic process
Biological Process GO:0006663 platelet activating factor biosynthetic process
Biological Process GO:0016032 viral process
molecular function GO:0047498 calcium-dependent phospholipase A2 activity
molecular function GO:0005544 calcium-dependent phospholipid binding
molecular function GO:0047499 calcium-independent phospholipase A2 activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0004622 lysophospholipase activity
molecular function GO:0008374 O-acyltransferase activity
molecular function GO:0102545 phosphatidyl phospholipase B activity
molecular function GO:0008970 phospholipase A1 activity
molecular function GO:0004623 phospholipase A2 activity
molecular function GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
molecular function GO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
molecular function GO:0005543 phospholipid binding
cellular component GO:0005938 cell cortex
cellular component GO:0005829 cytosol
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0005811 lipid droplet
cellular component GO:0016020 membrane
cellular component GO:0031966 mitochondrial membrane
cellular component GO:0005635 nuclear envelope
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1483115 Hydrolysis of LPC
R-HSA-1483152 Hydrolysis of LPE
R-HSA-1483206 Glycerophospholipid biosynthesis
R-HSA-1483257 Phospholipid metabolism
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0016382 BXGD001054 Flushing Pathological Conditions, Signs and Symptoms
C0017638 BXGD001132 Glioma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0202236 BXGD004086 Triglycerides measurement
C0334590 BXGD007129 Anaplastic Oligodendroglioma Neoplasms
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0677948 BXGD009739 Stage II Colorectal Cancer Digestive System Diseases; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C3146252 BXGD018261 Stage II Colorectal Cancer AJCC v7
C4529962 BXGD023178 Fatty Liver Disease
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005659 Arachidonic acid 304.47
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein