Showing entry for cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022210
Protein NamecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Uniport IdQ9Y233
GenePDE10A
Gene Id10846
DomainGAF; PDEase_I
Pfam PF01590   PF00233  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006198 cAMP catabolic process
Biological Process GO:0046069 cGMP catabolic process
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0043951 negative regulation of cAMP-mediated signaling
Biological Process GO:0010754 negative regulation of cGMP-mediated signaling
Biological Process GO:0010738 regulation of protein kinase A signaling
molecular function GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
molecular function GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
molecular function GO:0030552 cAMP binding
molecular function GO:0030553 cGMP binding
molecular function GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
molecular function GO:0046872 metal ion binding
cellular component GO:0005829 cytosol
cellular component GO:0016020 membrane
cellular component GO:0043204 perikaryon
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-392154 Nitric oxide stimulates guanylate cyclase
R-HSA-418346 Platelet homeostasis
R-HSA-418457 cGMP effects
R-HSA-418555 G alpha (s) signalling events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005612 BXGD000317 Birth Weight Pathological Conditions, Signs and Symptoms
C0005890 BXGD000345 Body Height
C0006012 BXGD000360 Borderline Personality Disorder Mental Disorders
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007370 BXGD000462 Catalepsy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0013132 BXGD000799 Drooling Stomatognathic Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021841 BXGD001519 Intestinal Neoplasms Digestive System Diseases; Neoplasms
C0023374 BXGD001639 Lesch-Nyhan Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085583 BXGD003194 Choreoathetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0149654 BXGD003343 Conduct Disorder Mental Disorders
C0152115 BXGD003544 Lingual-Facial-Buccal Dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0202230 BXGD004084 Thyroid stimulating hormone measurement
C0221169 BXGD004399 Hemiballismus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0349632 BXGD007939 Splenic Marginal Zone B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0426980 BXGD008599 Motor symptoms
C0428883 BXGD008639 Diastolic blood pressure
C0441683 BXGD008809 Hormone measurement
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0525041 BXGD009254 Neurobehavioral Manifestations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0679309 BXGD009765 physical symptom
C0679427 BXGD009777 myeloblastosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0740858 BXGD010012 Substance abuse problem Chemically-Induced Disorders; Mental Disorders
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0857501 BXGD011152 Acute schizophrenia
C0871470 BXGD011316 Systolic Pressure
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1611743 BXGD013456 Familial (FPAH)
C1846868 BXGD014846 Parkinsonism with favorable response to dopaminergic medication Nervous System Diseases
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854301 BXGD015391 Motor delay Mental Disorders
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1860787 BXGD015997 DOWN SYNDROME CRITICAL REGION Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3496069 BXGD019017 cocaine use
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3839460 BXGD019773 Nonprogressive
C3887506 BXGD019886 Hyperkinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4023343 BXGD021159 Nasogastric tube feeding in infancy
C4023607 BXGD021226 Abnormal corpus striatum morphology
C4310791 BXGD022667 STRIATAL DEGENERATION, AUTOSOMAL DOMINANT 2
C4310792 BXGD022668 DYSKINESIA, LIMB AND OROFACIAL, INFANTILE-ONSET
C4511452 BXGD023002 Sporadic Parkinson disease Nervous System Diseases
C4531279 BXGD023212 Striatal T2 hyperintensity
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000202 Papaverine 339.39
BXGC0000436 Glycerol 92.09
BXGC0000988 3' 5'-cyclic AMP 329.21
BXGC0001502 Caffeine 194.19
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0021234 Quinazolinone 146.05
BXGC0024261 Adenosine Phosphate 347.06
BXGC0027925 Cpg 363.06
BXGC0036634 Cgmp 345.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein