Showing entry for DNA polymerase eta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022216
Protein NameDNA polymerase eta
Uniport IdQ9Y253
GenePOLH
Gene Id5429
DomainIMS; IMS_C; zf_UBZ
Pfam PF00817   PF11799   PF18439  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01524 Platinum drug resistance
2. Genetic Information Processing 2.4 Replication and repair hsa03460 Fanconi anemia pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071494 cellular response to UV-C
Biological Process GO:0006281 DNA repair
Biological Process GO:0006260 DNA replication
Biological Process GO:0000731 DNA synthesis involved in DNA repair
Biological Process GO:0070987 error-free translesion synthesis
Biological Process GO:0042276 error-prone translesion synthesis
Biological Process GO:0006290 pyrimidine dimer repair
Biological Process GO:0006282 regulation of DNA repair
Biological Process GO:0009314 response to radiation
Biological Process GO:0010225 response to UV-C
Biological Process GO:0019985 translesion synthesis
molecular function GO:0003684 damaged DNA binding
molecular function GO:0003887 DNA-directed DNA polymerase activity
molecular function GO:0046872 metal ion binding
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005657 replication fork
cellular component GO:0035861 site of double-strand break
Reactome
Pathway Id Pathway Name
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
R-HSA-110320 Translesion Synthesis by POLH
R-HSA-5656169 Termination of translesion DNA synthesis
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693538 Homology Directed Repair
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
R-HSA-73893 DNA Damage Bypass
R-HSA-73894 DNA Repair
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009763 BXGD000628 Conjunctivitis Eye Diseases
C0013592 BXGD000857 Ectropion Eye Diseases
C0014390 BXGD000913 Entropion Eye Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0022568 BXGD001552 Keratitis Eye Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0039446 BXGD002811 Telangiectasis Cardiovascular Diseases
C0043345 BXGD003042 Xeroderma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0043346 BXGD003043 Xeroderma Pigmentosum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0085090 BXGD003122 Lymphoma, AIDS-Related Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0151514 BXGD003429 Atrophic condition of skin Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0162835 BXGD003989 Hypopigmentation disorder Skin and Connective Tissue Diseases
C0206701 BXGD004251 Cystadenocarcinoma, Serous Neoplasms
C0268135 BXGD005831 Xeroderma pigmentosum, group A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0268141 BXGD005835 Xeroderma pigmentosum, group G Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0346153 BXGD007781 Breast Cancer, Familial Neoplasms; Skin and Connective Tissue Diseases
C0349506 BXGD007912 Photosensitivity of skin Skin and Connective Tissue Diseases
C0392777 BXGD008068 Poikiloderma Pathological Conditions, Signs and Symptoms
C0398791 BXGD008233 Nijmegen Breakage Syndrome Nutritional and Metabolic Diseases
C0432328 BXGD008776 Xeroderma pigmentosum, variant form Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0751039 BXGD010302 Cockayne Syndrome, Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1519346 BXGD013235 Skin Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1848410 BXGD014922 Xeroderma pigmentosum, variant type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1859923 BXGD015942 Freckles in sun-exposed areas
C1963094 BXGD016681 Dry Skin, CTCAE
C2752147 BXGD017769 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000164 Oxoglaucine 351.35
BXGC0000286 L-DOPA 197.19
BXGC0000324 Isovitexin 432.38
BXGC0000340 Kaempferol 286.24
BXGC0000392 Eriodictyol 288.26
BXGC0000397 Diosmetin 7-rutinoside 608.54
BXGC0000436 Glycerol 92.09
BXGC0000805 Bis(2-furanylmethyl) disulfide 226.32
BXGC0000988 3' 5'-cyclic AMP 329.21
BXGC0001002 1,2-Benzenediol 110.11
BXGC0001024 Cirsimaritin 314.29
BXGC0001078 Xanthoangelol E 370.4
BXGC0001167 Isoorientin 7-O-(6'''-O-(E)-feruloyl)glucoside 448.38
BXGC0001498 Boldine 327.37
BXGC0001558 Papaveraldine 353.37
BXGC0001644 Quercetin 3-glucosyl-(1->2)-galactosyl-(1->2)-glucoside 788.66
BXGC0001691 Questiomycin A 212.2
BXGC0001742 Eupafolin 316.26
BXGC0001747 Rosmarinic acid 360.31
BXGC0001777 Schaftoside 564.49
BXGC0001782 Sennoside B 862.74
BXGC0001868 Catechin 290.27
BXGC0001940 Daphnetin 178.14
BXGC0001965 Hesperidin 610.56
BXGC0002018 Morin 302.24
BXGC0002064 Amentoflavone 538.46
BXGC0002071 Apigenin 270.24
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
BXGC0002906 Caffeic acid ester 284.31
BXGC0003273 3-O-Methylkaempferol 300.26
BXGC0003364 Cerebroside 299.49
BXGC0003456 1,4-Benzoquinone 108.09
BXGC0003696 Quercetin 3-O-methyl-ether 316.26
BXGC0003705 Chloride 35.45
BXGC0003852 Nigrin B 506.47
BXGC0004322 xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-Glucopyranoside 356.37
BXGC0004378 3-Hydroxyflavone 238.24
BXGC0004965 Rhein 284.22
BXGC0005319 Garcinone E 464.55
BXGC0005502 Coumestrol 268.22
BXGC0005667 Quercitrin 448.38
BXGC0005682 3,3',4,4'-Tetrahydroxylignan 302.36
BXGC0005683 Quercetin 302.24
BXGC0005793 Baicalein 270.24
BXGC0005945 2'-Hydroxygenistein 286.24
BXGC0005989 Auraptene 298.38
BXGC0006062 Isoorientin 448.38
BXGC0006107 alpha-Linolenic acid 278.43
BXGC0006193 Ellagic acid 302.19
BXGC0006306 Myricetin 318.24
BXGC0006308 Myricetin 3-rhamnoside 464.38
BXGC0006367 Mangiferin 422.34
BXGC0006635 Luteolin 286.24
BXGC0007029 Emodin 270.24
BXGC0007368 Luteolin 7-glucoside 448.38
BXGC0008365 Colubrinic acid 470.68
BXGC0008668 Isolicoflavonol 354.35
BXGC0008912 Panasenoside 610.52
BXGC0008943 Kaempferol 3-robinobioside 594.52
BXGC0009194 Quercetin 3-glucuronide 478.36
BXGC0010010 3,8''-Biapigenin 538.46
BXGC0010427 Xanthotoxol geranyl ether 338.4
BXGC0011207 (R)-Bitalin A 218.25
BXGC0011280 Isothymonin 360.31
BXGC0011390 Dihydroroseoside 388.45
BXGC0011421 3-Hydroxy-1-(4-hydroxyphenyl)-1-propanone 166.17
BXGC0011887 (3S,5R,6S,7E,9x)-7-Megastigmene-3,6,9-triol 9-glucoside 390.47
BXGC0012236 Quercetin 3-alpha-D-galactoside 464.38
BXGC0014059 2-Methoxy-1,4-Naphthoquinone 188.05
BXGC0016454 1-methoxyphaseollidin 354.15
BXGC0016681 Hispidin 246.05
BXGC0016886 Papaverine Hydrochloride 339.15
BXGC0017158 thunberginol A 270.05
BXGC0017701 Altenusin 290.08
BXGC0017933 Sulfuretin 270.05
BXGC0018004 \N 186.08
BXGC0019348 Angustibalin 304.13
BXGC0020737 Protoapigenone 286.05
BXGC0020995 6-[(3E,5E,7S)-5,7-Dimethyl-2-Oxonona-3,5-Dienyl]-2,4-Dihydroxy-3-Methylbenzaldehyde 316.17
BXGC0021478 Lipoic Acid 206.04
BXGC0021893 Norepinephrine 169.07
BXGC0022169 2-[(1S,6R)-6-(2,4-Dihydroxybenzoyl)-5-(2,4-Dihydroxyphenyl)-3-Methylcyclohex-2-En-1-Yl]-1,3,5A,8-Tetrahydroxy-10A-(3-Methylbut-2-Enyl)-[1]Benzofuro[3,2-B]Chromen-11-One 708.22
BXGC0022621 3-[(2S)-5,7-Dihydroxy-2-(4-Hydroxyphenyl)-3,4-Dihydro-2H-Chromen-8-Yl]-5,7-Dihydroxy-2-(4-Hydroxyphenyl)Chromen-4-One 526.13
BXGC0023321 Quercetin Dihydrate 302.04
BXGC0023895 (1R,4Ar,7R)-7-Ethenyl-1,4A,7-Trimethyl-3,4,4B,5,6,9,10,10A-Octahydro-2H-Phenanthrene-1-Carboxylic Acid 302.22
BXGC0024086 Gomisin M2 386.17
BXGC0024428 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One 333.15
BXGC0024665 Vitamin K 1 450.35
BXGC0025394 Scoulerine 327.15
BXGC0025862 Levothyroxine 776.69
BXGC0026480 Osajin 404.16
BXGC0026607 epiberberine 336.12
BXGC0026658 (E)-3-Phenyl-N-(2-Phenylethyl)Prop-2-Enamide 251.13
BXGC0027249 Deoxyvasicinone 186.08
BXGC0027277 6-Methoxycyclohexane-1,2,3,4,5-Pentol 194.08
BXGC0027536 Diosmin 608.17
BXGC0027565 Deoxyadenosine 251.1
BXGC0028001 Beta-Lapachone 242.09
BXGC0028589 5,6,7,8-Tetrahydroxy-2-(4-Hydroxyphenyl)Chromen-4-One 302.04
BXGC0029484 Cupressuflavone 538.09
BXGC0029598 2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyloxan-2-Yl]Oxychromen-4-One;Hydrate 448.1
BXGC0029601 EUPAROTIN ACETATE 418.16
BXGC0029721 Sclerotiorin 390.12
BXGC0030197 Prostaglandin B1 336.23
BXGC0031717 Purpurin 256.04
BXGC0033960 3-Hydroxybenzo[C]Chromen-6-One 212.05
BXGC0034049 3-[(2S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Oxy-2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxychromen-4-One 434.08
BXGC0034256 Rottlerin 516.18
BXGC0035226 Betulinic Acid 456.36
BXGC0036681 7,11B-Dihydro-6H-Indeno[2,1-C]Chromene-3,6A,9,10-Tetrol 286.08
BXGC0036860 Helenalin 262.12
BXGC0036918 5-Hydroxy-2-(4-Hydroxy-3,5-Dimethoxyphenyl)-6,7-Dimethoxychromen-4-One 374.1
BXGC0037599 Tanshinone Iia 294.13
BXGC0037718 Ethacrynic Acid 302.01
BXGC0037722 Pomiferin 420.16
BXGC0038083 Daphnorin 514.11
BXGC0038546 [(3Ar,4S,6Z,9E,11S,11Ar)-11-Hydroxy-6,10-Dimethyl-3-Methylidene-2,8-Dioxo-4,5,11,11A-Tetrahydro-3Ah-Cyclodeca[B]Furan-4-Yl] 2-Methylprop-2-Enoate 346.14
BXGC0038638 Gerontoxanthone A 394.14
BXGC0038895 Emodic Acid 300.03
BXGC0039397 Athraquinones A 240.04
BXGC0039520 [(3Ar,4S,6Z,9E,11S,11Ar)-11-Hydroxy-6,10-Dimethyl-3-Methylidene-2,8-Dioxo-4,5,11,11A-Tetrahydro-3Ah-Cyclodeca[B]Furan-4-Yl] (E)-2-Methylbut-2-Enoate 360.16
BXGC0040358 Lobaric Acid 456.18
BXGC0042046 Actinodaphnine 311.12
BXGC0042256 1,4-Bis[[(E)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoyl]Oxy]-3,5-Dihydroxycyclohexane-1-Carboxylic Acid 516.13
BXGC0042336 7-Amino-4-Hydroxynaphthalene-2-Sulfonic Acid 239.03
BXGC0042397 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-6-Methyl-2,3-Dihydrochromen-4-One 286.08
BXGC0042546 5-Hydroxy-2-(4-Hydroxyphenyl)-7-Methoxy-2,3-Dihydrochromen-4-One 286.08
BXGC0042678 Ambrosin 246.13
BXGC0042870 Piceatannol 244.07
BXGC0043026 (3S)-3,5,7-Trihydroxy-2-[(2S,3S)-3-(4-Hydroxy-3-Methoxyphenyl)-2-(Hydroxymethyl)-2,3-Dihydro-1,4-Benzodioxin-6-Yl]-2,3-Dihydrochromen-4-One 482.12
BXGC0043125 Taxifolin 304.06
BXGC0043790 2-(2-Acetyl-3,5-Dihydroxyphenyl)Acetic Acid 210.05
BXGC0044200 Menadione 172.05
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047405 Gamolenic Acid 278.22
BXGC0049858 Chalcone 208.09
BXGC0050184 Myricitrin 464.1
BXGC0050284 10-Hydroxycamptothecin 364.11
BXGC0050651 Cryptotanshinone 296.14
BXGC0050726 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-3-[(2R,3S,4R,5R,6S)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxychromen-4-One 448.1
BXGC0052374 Reserpine 608.27
BXGC0052948 Tanshinone I 276.08
BXGC0053274 4-(2,3-Dihydroxy-3-Methylbutoxy)Furo[3,2-G]Chromen-7-One 304.09
BXGC0053369 Centaureidin 360.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein