Showing entry for Phospholipase A-2-activating protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022220
Protein NamePhospholipase A-2-activating protein
Uniport IdQ9Y263
GenePLAA
Gene Id9373
DomainPFU; PUL; WD40
Pfam PF09070   PF08324   PF00400  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0006954 inflammatory response
Biological Process GO:0016236 macroautophagy
Biological Process GO:1900045 negative regulation of protein K63-linked ubiquitination
Biological Process GO:0006644 phospholipid metabolic process
Biological Process GO:1903861 positive regulation of dendrite extension
Biological Process GO:2001224 positive regulation of neuron migration
Biological Process GO:0032430 positive regulation of phospholipase A2 activity
Biological Process GO:1903423 positive regulation of synaptic vesicle recycling
Biological Process GO:0006693 prostaglandin metabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0007165 signal transduction
Biological Process GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Biological Process GO:0010992 ubiquitin recycling
molecular function GO:0016005 phospholipase A2 activator activity
molecular function GO:0043130 ubiquitin binding
cellular component GO:0005737 cytoplasm
cellular component GO:0070062 extracellular exosome
cellular component GO:0005634 nucleus
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007868 BXGD000498 Cervical dysplasia Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0019572 BXGD001338 Hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0024314 BXGD001767 Lymphoproliferative Disorders Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0034935 BXGD002497 Babinski Reflex
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036631 BXGD002626 Seminoma Neoplasms
C0039538 BXGD002819 Teratoma Neoplasms
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0158731 BXGD003902 Congenital pectus carinatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0221373 BXGD004454 Claw hand Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0232466 BXGD004543 Feeding difficulties
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0239234 BXGD004974 Low set ears
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0240912 BXGD005062 Vertical Talus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265554 BXGD005548 Ectrodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0343641 BXGD007636 Human papilloma virus infection Infections
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0424731 BXGD008542 Single transverse palmar crease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0431478 BXGD008692 Posteriorly rotated ear
C0431904 BXGD008713 Ulnar polydactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0432028 BXGD008714 Split foot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0456070 BXGD008863 Growth delay
C0494261 BXGD009023 Combined immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0523465 BXGD009209 Serum albumin measurement
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0813217 BXGD010854 Expressionless face Nervous System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1142533 BXGD011758 Smooth philtrum
C1274743 BXGD012043 Hyperhidrosis Palmaris Et Plantaris Skin and Connective Tissue Diseases
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1368898 BXGD012904 Adult Teratoma Neoplasms
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1608408 BXGD013434 Malignant transformation
C1740801 BXGD013744 Exaggerated startle response
C1837142 BXGD014201 Poor suck
C1838391 BXGD014313 Limb hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1839767 BXGD014404 Tented upper lip vermilion
C1842364 BXGD014511 Central hypotonia
C1844577 BXGD014647 Hyperextensibility of the finger joints
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1850456 BXGD015146 Progressive microcephaly
C1854114 BXGD015383 Short nose
C1855010 BXGD015450 Progressive leukoencephalopathy Nervous System Diseases
C1856019 BXGD015564 Abnormal cortical gyration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1856507 BXGD015614 Bulbar signs
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1858091 BXGD015771 Long fingers
C1859698 BXGD015923 Contractures of the large joints
C1859736 BXGD015929 Progressive spastic quadriplegia
C1861403 BXGD016045 Variable expressivity
C1865014 BXGD016282 Long philtrum
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2112129 BXGD016921 Postaxial foot polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C2347762 BXGD017050 Childhood Teratoma Neoplasms
C2732374 BXGD017553 Edema of dorsum of hand Pathological Conditions, Signs and Symptoms
C2919341 BXGD017871 Edema of dorsum of foot Pathological Conditions, Signs and Symptoms
C3278923 BXGD018748 Dilated ventricles (finding)
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4022735 BXGD020971 Cerebral white matter atrophy Pathological Conditions, Signs and Symptoms
C4024710 BXGD021381 Cerebellar cortical atrophy
C4025319 BXGD021642 Cessation of head growth
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4082299 BXGD022088 Bulbar palsy Nervous System Diseases
C4477013 BXGD022904 Impaired oropharyngeal swallow response Digestive System Diseases; Otorhinolaryngologic Diseases
C4479631 BXGD022943 NEURODEVELOPMENTAL DISORDER WITH PROGRESSIVE MICROCEPHALY, SPASTICITY, AND BRAIN ANOMALIES
C4551563 BXGD023351 Microcephaly (physical finding)
C4551583 BXGD023361 Cerebral cortical atrophy
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000204 Theophylline 180.16
BXGC0001623 L-Tryptophan 204.23
BXGC0002588 Magnesium 24.31
BXGC0003214 L-(-)-Phenylalanine 165.19
BXGC0032575 Leucine 131.09
BXGC0037242 Homoarginine 188.13
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein