Showing entry for Exosome complex exonuclease RRP44


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022240
Protein NameExosome complex exonuclease RRP44
Uniport IdQ9Y2L1
GeneDIS3
Gene Id22894
DomainOB_Dis3; PIN_4; RNB; Rrp44_CSD1; Rrp44_S1
Pfam PF17849   PF13638   PF00773   PF17216   PF17215  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa03018 RNA degradation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071034 CUT catabolic process
Biological Process GO:0043928 exonucleolytic catabolism of deadenylated mRNA
Biological Process GO:0043488 regulation of mRNA stability
Biological Process GO:0016075 rRNA catabolic process
Biological Process GO:0006364 rRNA processing
molecular function GO:0000175 3'-5'-exoribonuclease activity
molecular function GO:0004519 endonuclease activity
molecular function GO:0005085 guanyl-nucleotide exchange factor activity
molecular function GO:0003723 RNA binding
cellular component GO:0000177 cytoplasmic exosome (RNase complex)
cellular component GO:0005829 cytosol
cellular component GO:0000178 exosome (RNase complex)
cellular component GO:0016020 membrane
cellular component GO:0000176 nuclear exosome (RNase complex)
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-381042 PERK regulates gene expression
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-392499 Metabolism of proteins
R-HSA-429914 Deadenylation-dependent mRNA decay
R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72312 rRNA processing
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0087169 BXGD003321 Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0796113 BXGD010797 Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1136084 BXGD011708 Plasma cell dyscrasia Immune System Diseases; Hemic and Lymphatic Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein