Showing entry for Fanconi-associated nuclease 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022241
Protein NameFanconi-associated nuclease 1
Uniport IdQ9Y2M0
GeneFAN1
Gene Id22909
DomainVRR_NUC
Pfam PF08774  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03460 Fanconi anemia pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006281 DNA repair
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:0036297 interstrand cross-link repair
Biological Process GO:0006289 nucleotide-excision repair
Biological Process GO:0033683 nucleotide-excision repair, DNA incision
molecular function GO:0008409 5'-3' exonuclease activity
molecular function GO:0017108 5'-flap endonuclease activity
molecular function GO:0070336 flap-structured DNA binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0004528 phosphodiesterase I activity
molecular function GO:0140036 ubiquitin-dependent protein binding
cellular component GO:0005829 cytosol
cellular component GO:0045171 intercellular bridge
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-6783310 Fanconi Anemia Pathway
R-HSA-73894 DNA Repair
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0001816 BXGD000079 Agnosia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009405 BXGD000607 Hereditary Nonpolyposis Colorectal Neoplasms Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0017181 BXGD001103 Gastrointestinal Hemorrhage Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0017979 BXGD001159 Glycosuria Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027707 BXGD002024 Nephritis, Interstitial Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030554 BXGD002239 Paresthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0032000 BXGD002318 Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0034885 BXGD002490 Rectal Neoplasms Digestive System Diseases; Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0041349 BXGD002920 Nephritis, Tubulointerstitial Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042076 BXGD002956 Urologic Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0149793 BXGD003366 Amaurosis Fugax Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151539 BXGD003435 Blood urea increased Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151740 BXGD003468 Intracranial Hypertension Nervous System Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234144 BXGD004625 Dysgraphia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270971 BXGD006146 Floppy infant syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0347509 BXGD007857 Benign neoplasm of central nervous system Neoplasms; Nervous System Diseases
C0375206 BXGD007973 Hemiplegia/hemiparesis
C0477729 BXGD009008 Other chronic tubulo-interstitial nephritis
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0677898 BXGD009735 invasive cancer Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0687120 BXGD009837 Nephronophthisis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700225 BXGD009882 Serum creatinine raised Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1112155 BXGD011647 Hereditary non-polyposis colorectal cancer syndrome
C1257915 BXGD011813 Intestinal Polyposis Digestive System Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1333990 BXGD012670 Hereditary Nonpolyposis Colorectal Cancer Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C1333991 BXGD012671 Hereditary Non-Polyposis Colon Cancer Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C1392616 BXGD012977 Nonobstructive chronic pyelonephritis NOS
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1836830 BXGD014165 Developmental regression Mental Disorders
C1858430 BXGD015792 Death in infancy
C1963165 BXGD016685 Malabsorption, CTCAE
C1963167 BXGD016686 Memory Impairment, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2732838 BXGD017558 Neoplasm of skeletal system
C2931118 BXGD017961 Megalocytic interstitial nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2936783 BXGD018136 Colorectal cancer, hereditary nonpolyposis, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3553774 BXGD019188 INTERSTITIAL NEPHRITIS, KARYOMEGALIC
C3714745 BXGD019427 Malabsorption Digestive System Diseases
C3887499 BXGD019884 Renal cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3887875 BXGD019923 Visual field defects Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4020965 BXGD020514 Cardiac diverticulum
C4022012 BXGD020868 Death in early adulthood
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552810 BXGD023525 Irritability, CTCAE
C4553765 BXGD023551 Memory Impairment, CTCAE 5.0
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein