Showing entry for Thyroid hormone receptor-associated protein 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022249
Protein NameThyroid hormone receptor-associated protein 3
Uniport IdQ9Y2W1
GeneTHRAP3
Gene Id9967
DomainTHRAP3_BCLAF1
Pfam PF15440  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0006397 mRNA processing
Biological Process GO:0048255 mRNA stabilization
Biological Process GO:0000956 nuclear-transcribed mRNA catabolic process
Biological Process GO:0042753 positive regulation of circadian rhythm
Biological Process GO:0048026 positive regulation of mRNA splicing, via spliceosome
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0000381 regulation of alternative mRNA splicing, via spliceosome
Biological Process GO:0008380 RNA splicing
molecular function GO:0005524 ATP binding
molecular function GO:0003677 DNA binding
molecular function GO:0030374 nuclear receptor transcription coactivator activity
molecular function GO:0051219 phosphoprotein binding
molecular function GO:0003723 RNA binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0046966 thyroid hormone receptor binding
molecular function GO:0003713 transcription coactivator activity
molecular function GO:0003712 transcription coregulator activity
molecular function GO:0042809 vitamin D receptor binding
cellular component GO:0070062 extracellular exosome
cellular component GO:0016592 mediator complex
cellular component GO:0016607 nuclear speck
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1430728 Metabolism
R-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0153653 BXGD003675 Malignant tumor of parathyroid gland Neoplasms; Endocrine System Diseases
C0687150 BXGD009842 Parathyroid Gland Adenocarcinoma Neoplasms; Endocrine System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein