Showing entry for tRNA-splicing ligase RtcB homolog


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022259
Protein NametRNA-splicing ligase RtcB homolog
Uniport IdQ9Y3I0
GeneRTCB
Gene Id51493
DomainRtcB
Pfam PF01139  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0001890 placenta development
Biological Process GO:0000971 tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate
Biological Process GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
molecular function GO:0005525 GTP binding
molecular function GO:0046872 metal ion binding
molecular function GO:0003723 RNA binding
molecular function GO:0003972 RNA ligase (ATP) activity
molecular function GO:0017166 vinculin binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005635 nuclear envelope
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0072669 tRNA-splicing ligase complex
Reactome
Pathway Id Pathway Name
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-72306 tRNA processing
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002675 Sugars 342.3
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein