Showing entry for F-box only protein 7


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022260
Protein NameF-box only protein 7
Uniport IdQ9Y3I1
GeneFBXO7
Gene Id25793
DomainF-box; PI31_Prot_N
Pfam PF12937   PF11566  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000422 autophagy of mitochondrion
Biological Process GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Biological Process GO:1903208 negative regulation of hydrogen peroxide-induced neuron death
Biological Process GO:0045620 negative regulation of lymphocyte differentiation
Biological Process GO:1903204 negative regulation of oxidative stress-induced neuron death
Biological Process GO:1903599 positive regulation of autophagy of mitochondrion
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0006626 protein targeting to mitochondrion
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0040012 regulation of locomotion
Biological Process GO:0010975 regulation of neuron projection development
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0043130 ubiquitin binding
molecular function GO:1990756 ubiquitin ligase-substrate adaptor activity
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0004842 ubiquitin-protein transferase activity
cellular component GO:0097414 classical Lewy body
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0097409 glial cytoplasmic inclusion
cellular component GO:1990037 Lewy body core
cellular component GO:1990038 Lewy body corona
cellular component GO:0097462 Lewy neurite
cellular component GO:0005739 mitochondrion
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
cellular component GO:0019005 SCF ubiquitin ligase complex
cellular component GO:0000151 ubiquitin ligase complex
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0005697 BXGD000324 Neurogenic Urinary Bladder Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0012236 BXGD000772 DiGeorge Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0034935 BXGD002497 Babinski Reflex
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231688 BXGD004510 Gait, Shuffling Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231698 BXGD004517 Gait, Scissors Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233763 BXGD004611 Hallucinations, Visual Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234133 BXGD004624 Extrapyramidal sign
C0234376 BXGD004659 Action Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0263548 BXGD005325 Pyramidal disease Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Mental Disorders; Wounds and Injuries
C0265259 BXGD005487 Popliteal pterygium syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Musculoskeletal Diseases; Male Urogenital Diseases; Stomatognathic Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0685891 BXGD009824 Congenital hypoplasia of thymus Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0751772 BXGD010583 REM Sleep Behavior Disorder Nervous System Diseases; Mental Disorders
C0752105 BXGD010664 Parkinsonism, Juvenile Nervous System Diseases
C0813217 BXGD010854 Expressionless face Nervous System Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1263989 BXGD011906 Regenerative anemia Hemic and Lymphatic Diseases
C1271100 BXGD012007 Lower limb spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1285162 BXGD012167 Degenerative disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1321329 BXGD012430 Slowed saccades
C1368683 BXGD012900 Epithelioma Neoplasms
C1456687 BXGD013122 Polio and Post-Polio Syndrome Infections
C1843921 BXGD014620 Postural instability Nervous System Diseases
C1846865 BXGD014845 Substantia nigra gliosis Pathological Conditions, Signs and Symptoms
C1846868 BXGD014846 Parkinsonism with favorable response to dopaminergic medication Nervous System Diseases
C1850100 BXGD015108 PARKINSON DISEASE 15, AUTOSOMAL RECESSIVE (disorder) Eye Diseases; Nervous System Diseases
C1854494 BXGD015409 Slow progression
C1858479 BXGD015798 Spastic paraplegia 11, autosomal recessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1868596 BXGD016513 Atypical Parkinson Disease Nervous System Diseases
C1868675 BXGD016520 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE Nervous System Diseases
C2931356 BXGD018007 Spastic paraplegia type 5A, recessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2931845 BXGD018076 Neurodegeneration with brain iron accumulation (NBIA) Nutritional and Metabolic Diseases; Nervous System Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3550973 BXGD019143 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 5 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3554568 BXGD019222 Young adult onset
C4275179 BXGD022368 Young onset Parkinson disease Nervous System Diseases
C4511452 BXGD023002 Sporadic Parkinson disease Nervous System Diseases
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4531121 BXGD023189 Monotonic speech
C4553743 BXGD023548 Spasticity, CTCAE
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein