Showing entry for Transportin-3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022296
Protein NameTransportin-3
Uniport IdQ9Y5L0
GeneTNPO3
Gene Id23534
DomainXpo1
Pfam PF08389  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006606 protein import into nucleus
molecular function GO:0042802 identical protein binding
molecular function GO:0061608 nuclear import signal receptor activity
molecular function GO:0008536 Ran GTPase binding
cellular component GO:0005642 annulate lamellae
cellular component GO:0005737 cytoplasm
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005635 nuclear envelope
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000731 BXGD000002 Abdomen distended Digestive System Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0003962 BXGD000244 Ascites Pathological Conditions, Signs and Symptoms
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020541 BXGD001424 Portal Hypertension Digestive System Diseases
C0020651 BXGD001460 Hypotension, Orthostatic Nervous System Diseases; Cardiovascular Diseases
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0023418 BXGD001642 leukemia Neoplasms
C0023892 BXGD001715 Biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030232 BXGD002197 Pallor Pathological Conditions, Signs and Symptoms
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0033774 BXGD002419 Pruritus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0035369 BXGD002543 Retroviridae Infections Infections
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0040261 BXGD002855 Onychomycosis Infections; Skin and Connective Tissue Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0086942 BXGD003315 Rous Sarcoma Neoplasms; Infections; Animal Diseases
C0151480 BXGD003426 Anti-nuclear factor positive Skin and Connective Tissue Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151849 BXGD003486 Alkaline phosphatase raised Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0162834 BXGD003988 Hyperpigmentation Skin and Connective Tissue Diseases
C0200635 BXGD004041 Lymphocyte Count measurement
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0239981 BXGD005011 Hypoalbuminemia Hemic and Lymphatic Diseases
C0240953 BXGD005067 Winged scapula
C0268307 BXGD005892 Conjugated hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0343065 BXGD007595 Dermatographic urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0427063 BXGD008602 Shoulder girdle weakness
C0427064 BXGD008603 Pelvic girdle weakness Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0544966 BXGD009320 Autophagic vaculoes (finding)
C0560346 BXGD009475 Difficulty running Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0686353 BXGD009833 Muscular Dystrophies, Limb-Girdle Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0694563 BXGD009854 Excessive daytime somnolence
C1314665 BXGD012386 Serum alkaline phosphatase raised
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1535950 BXGD013325 Gastrointestinal inflammation
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1629609 BXGD013479 Age at menopause
C1842062 BXGD014492 MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1F Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1842170 BXGD014503 Centrally nucleated skeletal muscle fibers
C1853932 BXGD015366 Rimmed vacuoles on biopsy
C1866021 BXGD016363 Increased connective tissue
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C3148763 BXGD018270 MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1E Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4013182 BXGD020126 Caused by mutation in the transportin 3 gene (TNPO3, 610032.0001)
C4021726 BXGD020735 EMG: myopathic abnormalities Musculoskeletal Diseases; Nervous System Diseases
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4023577 BXGD021220 Abnormality of the intrahepatic bile duct
C4025565 BXGD021665 Late-onset distal muscle weakness
C4317107 BXGD022724 Abnormality of the thyroid gland
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein