Showing entry for NADPH oxidase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022302
Protein NameNADPH oxidase 1
Uniport IdQ9Y5S8
GeneNOX1
Gene Id27035
DomainFAD_binding_8; Ferric_reduct; NAD_binding_6
Pfam PF08022   PF01794   PF08030  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.8 Development hsa04380 Osteoclast differentiation
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04933 AGE-RAGE signaling pathway in diabetic complications
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001525 angiogenesis
Biological Process GO:0016477 cell migration
Biological Process GO:0071455 cellular response to hyperoxia
Biological Process GO:1990451 cellular stress response to acidic pH
Biological Process GO:0006952 defense response
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0042743 hydrogen peroxide metabolic process
Biological Process GO:0006954 inflammatory response
Biological Process GO:0051454 intracellular pH elevation
Biological Process GO:0006739 NADP metabolic process
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0072592 oxygen metabolic process
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0045726 positive regulation of integrin biosynthetic process
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:0010575 positive regulation of vascular endothelial growth factor production
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0034765 regulation of ion transmembrane transport
Biological Process GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
Biological Process GO:0045730 respiratory burst
Biological Process GO:0007165 signal transduction
Biological Process GO:0042554 superoxide anion generation
molecular function GO:0046872 metal ion binding
molecular function GO:0050661 NADP binding
molecular function GO:0048365 Rac GTPase binding
molecular function GO:0016175 superoxide-generating NADPH oxidase activity
molecular function GO:0005244 voltage-gated ion channel activity
cellular component GO:0030054 cell junction
cellular component GO:0005769 early endosome
cellular component GO:0071438 invadopodium membrane
cellular component GO:0043020 NADPH oxidase complex
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-5663205 Infectious disease
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
R-HSA-9658195 Leishmania infection
R-HSA-9664420 Killing mechanisms
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011195 BXGD000702 Dejerine-Sottas Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0011269 BXGD000710 Dementia, Vascular Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013370 BXGD000822 Amebic colitis Digestive System Diseases; Infections
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017152 BXGD001096 Gastritis Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018203 BXGD001184 Chronic granulomatous disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031306 BXGD002298 Phagocyte Bactericidal Dysfunction Immune System Diseases; Hemic and Lymphatic Diseases
C0032914 BXGD002379 Pre-Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035344 BXGD002541 Retinopathy of Prematurity Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0162770 BXGD003980 Right Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202236 BXGD004086 Triglycerides measurement
C0221032 BXGD004374 Familial generalized lipodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0235782 BXGD004769 Gallbladder Carcinoma Digestive System Diseases; Neoplasms
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0267952 BXGD005794 Fibrosis of pancreas Digestive System Diseases
C0268902 BXGD006048 Atrophy of seminal vesicle
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0333307 BXGD006946 Superficial ulcer Pathological Conditions, Signs and Symptoms
C0333516 BXGD006957 Tumor necrosis Pathological Conditions, Signs and Symptoms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0563625 BXGD009484 Agnosia for Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0748355 BXGD010195 Acute respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0752125 BXGD010673 Spinocerebellar Ataxia Type 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0850666 BXGD010901 Infection caused by Helicobacter pylori Infections
C0856169 BXGD011096 Endothelial dysfunction
C0917996 BXGD011425 Cerebral Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0949272 BXGD011573 IIeocolitis Digestive System Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1368683 BXGD012900 Epithelioma Neoplasms
C1397307 BXGD012996 Cardiac fibrosis
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510885 BXGD013178 Angiogenic Switch
C1519346 BXGD013235 Skin Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1533172 BXGD013311 Infantile nystagmus syndrome Eye Diseases; Nervous System Diseases
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1719672 BXGD013659 Severe Sepsis Pathological Conditions, Signs and Symptoms; Infections
C1844376 BXGD014627 Granulomatous Disease, Chronic, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C1848296 BXGD014918 DOSAGE-SENSITIVE SEX REVERSAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363973 BXGD017121 Chronic thromboembolic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2609253 BXGD017172 Macrovascular disease
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3887524 BXGD019892 Skin Erosion Skin and Connective Tissue Diseases
C4525297 BXGD023131 Stage 0 Gallbladder Cancer AJCC v8
C4525300 BXGD023132 Stage IIA Gallbladder Cancer AJCC v8
C4525301 BXGD023133 Stage IIB Gallbladder Cancer AJCC v8
C4525302 BXGD023134 Stage III Gallbladder Cancer AJCC v8
C4525305 BXGD023135 Stage IV Gallbladder Cancer AJCC v8
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003066 Phenols 199.27
BXGC0045812 Trifluoperazine 407.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein