Showing entry for Photoreceptor-specific nuclear receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022306
Protein NamePhotoreceptor-specific nuclear receptor
Uniport IdQ9Y5X4
GeneNR2E3
Gene Id10002
DomainHormone_recep; zf-C4
Pfam PF00104   PF00105  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0048856 anatomical structure development
Biological Process GO:0030154 cell differentiation
Biological Process GO:0042462 eye photoreceptor cell development
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0007602 phototransduction
Biological Process GO:0045872 positive regulation of rhodopsin gene expression
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0060041 retina development in camera-type eye
Biological Process GO:0007165 signal transduction
Biological Process GO:0006367 transcription initiation from RNA polymerase II promoter
Biological Process GO:0007601 visual perception
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0004879 nuclear receptor activity
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:0003707 steroid hormone receptor activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005667 transcription regulator complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004623 BXGD000282 Bacterial Infections Infections
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018975 BXGD001259 Hemeralopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0024440 BXGD001774 Macular Edema, Cystoid Eye Diseases
C0026936 BXGD001950 Mycoplasma Infections Infections
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0034931 BXGD002495 Reflex Sympathetic Dystrophy Nervous System Diseases
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035313 BXGD002532 Retinal Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0042798 BXGD003003 Low Vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152200 BXGD003557 Achromatopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0152439 BXGD003593 Retinoschisis Eye Diseases
C0154850 BXGD003750 Cystoid macular retinal degeneration Eye Diseases
C0155016 BXGD003765 Color Blindness, Red-Green Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0155017 BXGD003766 Color Blindness, Blue Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0234629 BXGD004690 Abnormal color vision
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0271051 BXGD006153 Macular retinal edema Eye Diseases
C0271093 BXGD006162 Stargardt's disease
C0271185 BXGD006170 Metamorphopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0271385 BXGD006193 Horizontal Nystagmus Eye Diseases; Nervous System Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0302129 BXGD006830 Achromatopsia 1 Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0339525 BXGD007258 Autosomal dominant retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0339526 BXGD007259 Autosomal recessive retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0339527 BXGD007260 Leber Congenital Amaurosis Eye Diseases
C0339537 BXGD007264 Cone monochromatism Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0339541 BXGD007266 Goldmann-Favre syndrome (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0344290 BXGD007662 Vitreoretinal degeneration
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0524801 BXGD009244 Retinal Neoplasms Neoplasms; Eye Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0730362 BXGD009961 Disorder of macula of retina Eye Diseases
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C1840077 BXGD014434 Anteverted nostril
C1848172 BXGD014908 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1849367 BXGD015046 Nasal bridge wide
C1849394 BXGD015048 Enhanced S-Cone Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1855685 BXGD015531 Undetectable electroretinogram
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1970163 BXGD016811 RETINITIS PIGMENTOSA 37 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1998028 BXGD016865 Photoreceptor degeneration Eye Diseases
C2931258 BXGD017991 Amaurosis congenita of Leber, type 1 Eye Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021570 BXGD020678 Undetectable light- and dark-adapted electroretinogram
C4021786 BXGD020779 Atypical scarring of skin Pathological Conditions, Signs and Symptoms
C4024818 BXGD021428 Progressive night blindness Eye Diseases
C4085590 BXGD022119 Cone-Rod Dystrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4316870 BXGD022707 Abnormality of the eye
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003534 Mangiferol 422.34
BXGC0006367 Mangiferin 422.34
BXGC0029291 Diphyllin 380.09
BXGC0036860 Helenalin 262.12
BXGC0050284 10-Hydroxycamptothecin 364.11
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein