Showing entry for Sodium channel protein type 10 subunit alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022309
Protein NameSodium channel protein type 10 subunit alpha
Uniport IdQ9Y5Y9
GeneSCN10A
Gene Id6336
DomainIon_trans; Na_trans_assoc
Pfam PF00520   PF06512  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0086016 AV node cell action potential
Biological Process GO:0086043 bundle of His cell action potential
Biological Process GO:0086010 membrane depolarization during action potential
Biological Process GO:0019228 neuronal action potential
Biological Process GO:0042475 odontogenesis of dentin-containing tooth
Biological Process GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
Biological Process GO:0055117 regulation of cardiac muscle contraction
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0034765 regulation of ion transmembrane transport
Biological Process GO:0007600 sensory perception
Biological Process GO:0019233 sensory perception of pain
Biological Process GO:0035725 sodium ion transmembrane transport
molecular function GO:0005261 cation channel activity
molecular function GO:0044325 ion channel binding
molecular function GO:0005244 voltage-gated ion channel activity
molecular function GO:0005248 voltage-gated sodium channel activity
cellular component GO:0030424 axon
cellular component GO:0071439 clathrin complex
cellular component GO:0070062 extracellular exosome
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0099056 integral component of presynaptic membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0001518 voltage-gated sodium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-373760 L1CAM interactions
R-HSA-397014 Muscle contraction
R-HSA-422475 Axon guidance
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5576891 Cardiac conduction
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002768 BXGD000128 Congenital Pain Insensitivity Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004245 BXGD000264 Atrioventricular Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004331 BXGD000268 Auriculo-Ventricular Dissociation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007760 BXGD000476 Cerebellar Diseases Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0011071 BXGD000696 Sudden death Pathological Conditions, Signs and Symptoms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0013395 BXGD000831 Dyspepsia Pathological Conditions, Signs and Symptoms
C0014804 BXGD000951 Erythromelalgia Cardiovascular Diseases
C0014805 BXGD000952 Primary Erythermalgia Cardiovascular Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018794 BXGD001222 Heart Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018803 BXGD001228 Heart Function Tests
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0020075 BXGD001359 Hereditary Sensory Autonomic Neuropathy, Type 5 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020621 BXGD001449 Hypokalemia Nutritional and Metabolic Diseases
C0020672 BXGD001461 Hypothermia, natural Pathological Conditions, Signs and Symptoms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022650 BXGD001568 Kidney Calculi Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030591 BXGD002247 Paroxysmal ventricular tachycardia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0033774 BXGD002419 Pruritus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0035828 BXGD002566 Romano-Ward Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037052 BXGD002662 Sick Sinus Syndrome Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0038870 BXGD002782 Neuralgia, Supraorbital Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039240 BXGD002804 Supraventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040479 BXGD002870 Torsades de Pointes Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0041834 BXGD002935 Erythema Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0042384 BXGD002979 Vasculitis Cardiovascular Diseases
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042656 BXGD002995 Neuralgia, Vidian Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0085610 BXGD003202 Sinus bradycardia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085614 BXGD003205 First degree atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085615 BXGD003206 Right bundle branch block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0149940 BXGD003391 Sciatic Neuropathy Nervous System Diseases
C0151854 BXGD003487 Abnormal platelets Hemic and Lymphatic Diseases
C0151879 BXGD003496 Shortened QT interval Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0152020 BXGD003519 Gastroparesis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0155707 BXGD003813 Trifascicular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0234247 BXGD004642 Neuralgia, Atypical Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234249 BXGD004643 Neuralgia, Stump Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235480 BXGD004751 Paroxysmal atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242966 BXGD005201 Systemic Inflammatory Response Syndrome Pathological Conditions, Signs and Symptoms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0264716 BXGD005417 Chronic heart failure Cardiovascular Diseases
C0264886 BXGD005432 Conduction disorder of the heart Cardiovascular Diseases
C0264893 BXGD005433 Nodal rhythm disorder Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0334634 BXGD007144 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0348626 BXGD007878 Other specified cardiac arrhythmias Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0349788 BXGD007956 Arrhythmogenic Right Ventricular Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0391976 BXGD008022 Pain Disorder Mental Disorders
C0392525 BXGD008052 Nephrolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0423711 BXGD008498 Neuralgia, Perineal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0423712 BXGD008499 Neuralgia, Iliohypogastric Nerve Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0428908 BXGD008641 Sinus Node Dysfunction (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0429021 BXGD008645 P wave duration (observable entity)
C0429028 BXGD008646 QT interval feature (observable entity)
C0429087 BXGD008647 Electrocardiogram: P-R interval
C0429097 BXGD008648 QRS complex feature
C0458247 BXGD008904 Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0520886 BXGD009118 ST segment elevation (finding) Cardiovascular Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751211 BXGD010350 Hyperalgesia, Primary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751212 BXGD010351 Hyperalgesia, Secondary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751213 BXGD010352 Tactile Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751371 BXGD010415 Neuralgia, Ilioinguinal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751372 BXGD010416 Nerve Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751373 BXGD010417 Paroxysmal Nerve Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1142166 BXGD011736 Brugada Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1399226 BXGD013003 Ectopic rhythm Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1560249 BXGD013361 Adverse Event Associated with Cardiac Arrhythmia
C1560305 BXGD013362 Prolonged QTc interval
C1623258 BXGD013476 Electrocardiography
C1631597 BXGD013480 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1719672 BXGD013659 Severe Sepsis Pathological Conditions, Signs and Symptoms; Infections
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1721096 BXGD013704 Brugada ECG Pattern Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1821417 BXGD013764 RESTING HEART RATE
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1833661 BXGD013935 PAROXYSMAL EXTREME PAIN DISORDER Pathological Conditions, Signs and Symptoms
C1839341 BXGD014370 Abnormal T-wave
C1855739 BXGD015538 Indifference to Pain, Congenital, Autosomal Recessive Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1963175 BXGD016687 Sinus Bradycardia, CTCAE
C1963217 BXGD016689 Prolonged QTc Interval, CTCAE
C2108107 BXGD016920 continuous electrocardiogram sinus bradycardia (finding)
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2585653 BXGD017139 Persistent atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2748542 BXGD017596 CARDIAC CONDUCTION DEFECT, NONSPECIFIC (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3276706 BXGD018694 Small Fiber Neuropathy Nervous System Diseases
C3468561 BXGD018908 familial atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C3715208 BXGD019451 AV Block First Degree by ECG Finding Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C3809893 BXGD019619 EPISODIC PAIN SYNDROME, FAMILIAL, 2
C4025797 BXGD021795 Abnormality of prenatal development or birth
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4477077 BXGD022917 Abnormal cardiac exercise stress test
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4551804 BXGD023411 Brugada Syndrome 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0024988 Nifedipine 346.12
BXGC0049369 Tetrodotoxin 319.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein