Showing entry for Nuclear receptor corepressor 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022315
Protein NameNuclear receptor corepressor 2
Uniport IdQ9Y618
GeneNCOR2
Gene Id9612
DomainGPS2_interact; Myb_DNA-binding
Pfam PF15784   PF00249  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04330 Notch signaling pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0044849 estrous cycle
Biological Process GO:0007595 lactation
Biological Process GO:0060766 negative regulation of androgen receptor signaling pathway
Biological Process GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0010565 regulation of cellular ketone metabolic process
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:0032355 response to estradiol
Biological Process GO:0010243 response to organonitrogen compound
molecular function GO:0003682 chromatin binding
molecular function GO:0035259 glucocorticoid receptor binding
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0005112 Notch binding
molecular function GO:0035257 nuclear hormone receptor binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0047485 protein N-terminus binding
molecular function GO:0046965 retinoid X receptor binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:0003714 transcription corepressor activity
cellular component GO:0000118 histone deacetylase complex
cellular component GO:0016020 membrane
cellular component GO:0016604 nuclear body
cellular component GO:0000790 nuclear chromatin
cellular component GO:0016363 nuclear matrix
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0017053 transcription repressor complex
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1430728 Metabolism
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-1980143 Signaling by NOTCH1
R-HSA-1989781 PPARA activates gene expression
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-212436 Generic Transcription Pathway
R-HSA-212436 Generic Transcription Pathway
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603 Signaling by NOTCH1 in Cancer
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2990846 SUMOylation
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-350054 Notch-HLH transcription pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-392499 Metabolism of proteins
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-4839726 Chromatin organization
R-HSA-556833 Metabolism of lipids
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5663205 Infectious disease
R-HSA-597592 Post-translational protein modification
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-74160 Gene expression (Transcription)
R-HSA-8986944 Transcriptional Regulation by MECP2
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome
R-HSA-9005895 Pervasive developmental disorders
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9006936 Signaling by TGFB family members
R-HSA-9006936 Signaling by TGFB family members
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex
R-HSA-9022692 Regulation of MECP2 expression and activity
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-HSA-9609646 HCMV Infection
R-HSA-9609690 HCMV Early Events
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
R-HSA-9675151 Disorders of Developmental Biology
R-HSA-9697154 Disorders of Nervous System Development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001815 BXGD000078 Primary Myelofibrosis Hemic and Lymphatic Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014173 BXGD000903 Endometrial Hyperplasia Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023418 BXGD001642 leukemia Neoplasms
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0026987 BXGD001957 Myelofibrosis Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028756 BXGD002083 Obesity, Morbid Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0042834 BXGD003004 Vital capacity
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200638 BXGD004043 Eosinophil count procedure
C0220605 BXGD004294 Adult Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220612 BXGD004296 Childhood Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0231341 BXGD004492 Premature aging syndrome Pathological Conditions, Signs and Symptoms
C0271801 BXGD006262 Central hypothyroidism Endocrine System Diseases
C0278493 BXGD006517 Breast cancer recurrent Neoplasms; Skin and Connective Tissue Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0349141 BXGD007891 Mental and behavioral disorders due to use of cocaine, unspecified mental and behavioral disorder
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424678 BXGD008537 Lean body mass
C0428883 BXGD008639 Diastolic blood pressure
C0521158 BXGD009130 Recurrent tumor
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1536010 BXGD013330 Lymphoma transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1849718 BXGD015080 POPLITEAL PTERYGIUM SYNDROME, LETHAL TYPE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2745900 BXGD017568 Promyelocytic leukemia
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4273988 BXGD022339 Benign adult familial myoclonic epilepsy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4722330 BXGD023801 Generalized Thyroid Hormone Resistance Endocrine System Diseases
C4726581 BXGD023845 Transformed Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006367 Mangiferin 422.34
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein