Showing entry for Dual specificity protein phosphatase 10


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022342
Protein NameDual specificity protein phosphatase 10
Uniport IdQ9Y6W6
GeneDUSP10
Gene Id11221
DomainDSPc; Rhodanese
Pfam PF00782   PF00581  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0016311 dephosphorylation
Biological Process GO:0000188 inactivation of MAPK activity
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0010633 negative regulation of epithelial cell migration
Biological Process GO:0050680 negative regulation of epithelial cell proliferation
Biological Process GO:1905042 negative regulation of epithelium regeneration
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:0046329 negative regulation of JNK cascade
Biological Process GO:0043508 negative regulation of JUN kinase activity
Biological Process GO:0048715 negative regulation of oligodendrocyte differentiation
Biological Process GO:1903753 negative regulation of p38MAPK cascade
Biological Process GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation
Biological Process GO:0060266 negative regulation of respiratory burst involved in inflammatory response
Biological Process GO:0048709 oligodendrocyte differentiation
Biological Process GO:0035970 peptidyl-threonine dephosphorylation
Biological Process GO:0035335 peptidyl-tyrosine dephosphorylation
Biological Process GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
Biological Process GO:0045591 positive regulation of regulatory T cell differentiation
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0002819 regulation of adaptive immune response
Biological Process GO:0090335 regulation of brown fat cell differentiation
Biological Process GO:0032496 response to lipopolysaccharide
molecular function GO:0008432 JUN kinase binding
molecular function GO:0033549 MAP kinase phosphatase activity
molecular function GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
molecular function GO:0051019 mitogen-activated protein kinase binding
molecular function GO:0048273 mitogen-activated protein kinase p38 binding
molecular function GO:0016791 phosphatase activity
molecular function GO:0004721 phosphoprotein phosphatase activity
molecular function GO:0008330 protein tyrosine/threonine phosphatase activity
molecular function GO:0004725 protein tyrosine phosphatase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016607 nuclear speck
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-9607240 FLT3 Signaling
R-HSA-9652817 Signaling by MAPK mutants
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009443 BXGD000612 Common Cold Infections; Respiratory Tract Diseases
C0011195 BXGD000702 Dejerine-Sottas Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0024266 BXGD001754 Lymphocytic Choriomeningitis Infections; Nervous System Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0038868 BXGD002781 Progressive supranuclear palsy Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0153014 BXGD003612 Non-arthropod borne lymphocytic choriomeningitis Infections; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0276447 BXGD006425 Rhinovirus infection Infections
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0729531 BXGD009928 Viral respiratory infection Infections; Respiratory Tract Diseases
C0877009 BXGD011326 Muscle fibrosis
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1848296 BXGD014918 DOSAGE-SENSITIVE SEX REVERSAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein