protein

Showing entry for Voltage-dependent calcium channel subunit alpha-2/delta-4

General Target Information
BXGT Id	BXGT022658
Protein Name	Voltage-dependent calcium channel subunit alpha-2/delta-4
Uniport Id	Q7Z3S7
Gene	CACNA2D4
Gene Id	93589
Domain	VGCC_alpha2; VWA_3; VWA_N
Pfam	PF08473 PF13768 PF08399
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
3. Environmental Information Processing	3.2 Signal transduction	hsa04010	MAPK signaling pathway
5. Organismal Systems	5.3 Circulatory system	hsa04260	Cardiac muscle contraction
5. Organismal Systems	5.3 Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes
5. Organismal Systems	5.2 Endocrine system	hsa04921	Oxytocin signaling pathway
6. Human Diseases	6.6 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)
6. Human Diseases	6.6 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases	6.6 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy (DCM)

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0070588	calcium ion transmembrane transport
Biological Process	GO:0061337	cardiac conduction
Biological Process	GO:0050908	detection of light stimulus involved in visual perception
Biological Process	GO:0034765	regulation of ion transmembrane transport
molecular function	GO:0046872	metal ion binding
molecular function	GO:0005245	voltage-gated calcium channel activity
cellular component	GO:0005886	plasma membrane
cellular component	GO:0005891	voltage-gated calcium channel complex

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0003850	BXGD000225	Arteriosclerosis	Cardiovascular Diseases
C0004153	BXGD000260	Atherosclerosis	Cardiovascular Diseases
C0004238	BXGD000262	Atrial Fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004936	BXGD000295	Mental disorders	Mental Disorders
C0006012	BXGD000360	Borderline Personality Disorder	Mental Disorders
C0006287	BXGD000390	Bronchopulmonary Dysplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0009398	BXGD000604	Color vision defect	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0015397	BXGD000983	Disorder of eye	Eye Diseases
C0019693	BXGD001346	HIV Infections	Infections; Immune System Diseases
C0028077	BXGD002069	Nyctalopia	Eye Diseases
C0028738	BXGD002081	Nystagmus	Eye Diseases; Nervous System Diseases
C0038379	BXGD002752	Strabismus	Eye Diseases; Nervous System Diseases
C0085636	BXGD003218	Photophobia	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0233514	BXGD004584	Abnormal behavior	Behavior and Behavior Mechanisms
C0234632	BXGD004691	Reduced visual acuity	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0235095	BXGD004723	Visual field constriction	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0271183	BXGD006169	Severe myopia	Eye Diseases
C0339535	BXGD007263	Night blindness, congenital stationary	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0596887	BXGD009648	mathematical ability
C0730290	BXGD009946	Cone Dystrophy	Eye Diseases
C0871470	BXGD011316	Systolic Pressure
C1298695	BXGD012251	Hypoplasia of optic disc	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1857644	BXGD015728	Retinal pigment epithelial mottling
C1862475	BXGD016132	Abnormality of retinal pigmentation
C1864849	BXGD016257	RETINAL CONE DYSTROPHY 4	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1963184	BXGD016688	Nystagmus, CTCAE 3.0
C2363741	BXGD017100	HIV-1 infection
C3489532	BXGD018934	Cone-Rod Dystrophy 2	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3665347	BXGD019279	Visual Impairment	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4021561	BXGD020672	Electronegative electroretinogram
C4024756	BXGD021405	Abnormality of macular pigmentation
C4085590	BXGD022119	Cone-Rod Dystrophies	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036	BXGD023557	Nystagmus, CTCAE 5.0

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0003611	Latex		416.57
BXGC0006372	Ergocalciferol		396.65
BXGC0024988	Nifedipine		346.12

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}