protein

Showing entry for Diacylglycerol kinase delta

General Target Information
BXGT Id	BXGT022666
Protein Name	Diacylglycerol kinase delta
Uniport Id	Q16760
Gene	DGKD
Gene Id	8527
Domain	C1_1; DAGK_acc; DAGK_cat; PH; SAM_2
Pfam	PF00130 PF00609 PF00781 PF00169 PF07647
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
1. Metabolism	1.3 Lipid metabolism	hsa00561	Glycerolipid metabolism
1. Metabolism	1.3 Lipid metabolism	hsa00564	Glycerophospholipid metabolism
1. Metabolism	1.0 Global and overview maps	hsa01100	Metabolic pathways
3. Environmental Information Processing	3.2 Signal transduction	hsa04070	Phosphatidylinositol signaling system
3. Environmental Information Processing	3.2 Signal transduction	hsa04072	Phospholipase D signaling pathway
6. Human Diseases	6.1 Cancers: Overview	hsa05231	Choline metabolism in cancer

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0046339	diacylglycerol metabolic process
Biological Process	GO:0006897	endocytosis
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway
Biological Process	GO:0046486	glycerolipid metabolic process
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0046834	lipid phosphorylation
Biological Process	GO:0007275	multicellular organism development
Biological Process	GO:0090038	negative regulation of protein kinase C signaling
Biological Process	GO:0006654	phosphatidic acid biosynthetic process
Biological Process	GO:0030168	platelet activation
Biological Process	GO:2000370	positive regulation of clathrin-dependent endocytosis
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway
Biological Process	GO:0015031	protein transport
Biological Process	GO:0010033	response to organic substance
Biological Process	GO:0019932	second-messenger-mediated signaling
Biological Process	GO:0007165	signal transduction
molecular function	GO:0005524	ATP binding
molecular function	GO:0019992	diacylglycerol binding
molecular function	GO:0004143	diacylglycerol kinase activity
molecular function	GO:0042802	identical protein binding
molecular function	GO:0019900	kinase binding
molecular function	GO:0046872	metal ion binding
molecular function	GO:0003951	NAD+ kinase activity
molecular function	GO:0046982	protein heterodimerization activity
molecular function	GO:0042803	protein homodimerization activity
cellular component	GO:0005905	clathrin-coated pit
cellular component	GO:0005737	cytoplasm
cellular component	GO:0031410	cytoplasmic vesicle
cellular component	GO:0005829	cytosol
cellular component	GO:0005634	nucleus
cellular component	GO:0005886	plasma membrane

Reactome

Pathway Id	Pathway Name
R-HSA-109582	Hemostasis
R-HSA-114508	Effects of PIP2 hydrolysis
R-HSA-162582	Signal Transduction
R-HSA-372790	Signaling by GPCR
R-HSA-388396	GPCR downstream signalling
R-HSA-416476	G alpha (q) signalling events
R-HSA-76002	Platelet activation, signaling and aggregation

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0005938	BXGD000351	Bone Density
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0017612	BXGD001129	Glaucoma, Open-Angle	Eye Diseases
C0020456	BXGD001392	Hyperglycemia	Nutritional and Metabolic Diseases
C0022650	BXGD001568	Kidney Calculi	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028768	BXGD002084	Obsessive-Compulsive Disorder	Mental Disorders
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0036572	BXGD002625	Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0201925	BXGD004058	Calcium measurement
C0238111	BXGD004877	Lennox-Gastaut syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0344395	BXGD007668	Bilirubin measurement
C0392525	BXGD008052	Nephrolithiasis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0428302	BXGD008625	Calcium level result
C0523465	BXGD009209	Serum albumin measurement
C1287365	BXGD012174	Bilirubin level result
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C3807541	BXGD019532	MACROCEPHALY AND EPILEPTIC ENCEPHALOPATHY

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0037274	(+)-Alpha-Tocopheryl Succinate		530.4

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}