Showing entry for Diacylglycerol kinase iota


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022670
Protein NameDiacylglycerol kinase iota
Uniport IdO75912
GeneDGKI
Gene Id9162
DomainC1_1; DAGK_acc; DAGK_cat
Pfam PF12796   PF00130   PF00609   PF00781  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00561 Glycerolipid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00564 Glycerophospholipid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05231 Choline metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046339 diacylglycerol metabolic process
Biological Process GO:0060079 excitatory postsynaptic potential
Biological Process GO:0046486 glycerolipid metabolic process
Biological Process GO:0046959 habituation
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0046834 lipid phosphorylation
Biological Process GO:0007269 neurotransmitter secretion
Biological Process GO:0030168 platelet activation
Biological Process GO:0046579 positive regulation of Ras protein signal transduction
Biological Process GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:1900452 regulation of long-term synaptic depression
Biological Process GO:0051966 regulation of synaptic transmission, glutamatergic
Biological Process GO:2000300 regulation of synaptic vesicle exocytosis
molecular function GO:0005524 ATP binding
molecular function GO:0004143 diacylglycerol kinase activity
molecular function GO:0005095 GTPase inhibitor activity
molecular function GO:0046872 metal ion binding
molecular function GO:0003951 NAD+ kinase activity
molecular function GO:0017016 Ras GTPase binding
cellular component GO:0043679 axon terminus
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0043197 dendritic spine
cellular component GO:0060076 excitatory synapse
cellular component GO:0099147 extrinsic component of postsynaptic density membrane
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0032045 guanyl-nucleotide exchange factor complex
cellular component GO:0043025 neuronal cell body
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0048786 presynaptic active zone
cellular component GO:0032991 protein-containing complex
cellular component GO:0098685 Schaffer collateral - CA1 synapse
cellular component GO:0045202 synapse
cellular component GO:0008021 synaptic vesicle
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-76002 Platelet activation, signaling and aggregation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001175 BXGD000029 Acquired Immunodeficiency Syndrome Infections; Immune System Diseases
C0008074 BXGD000519 Child Development Disorders, Pervasive Mental Disorders
C0013537 BXGD000853 Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0339525 BXGD007258 Autosomal dominant retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0476254 BXGD008984 Dyslexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C1305855 BXGD012348 Body mass index
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1998028 BXGD016865 Photoreceptor degeneration Eye Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0037274 (+)-Alpha-Tocopheryl Succinate 530.4
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein