Showing entry for Growth hormone secretagogue receptor type 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022673
Protein NameGrowth hormone secretagogue receptor type 1
Uniport IdQ92847
GeneGHSR
Gene Id2693
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008154 actin polymerization or depolymerization
Biological Process GO:0008343 adult feeding behavior
Biological Process GO:1990314 cellular response to insulin-like growth factor stimulus
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0097067 cellular response to thyroid hormone stimulus
Biological Process GO:0046697 decidualization
Biological Process GO:0036321 ghrelin secretion
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0030252 growth hormone secretion
Biological Process GO:0009755 hormone-mediated signaling pathway
Biological Process GO:0007611 learning or memory
Biological Process GO:0032099 negative regulation of appetite
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0046676 negative regulation of insulin secretion
Biological Process GO:0032691 negative regulation of interleukin-1 beta production
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:0090327 negative regulation of locomotion involved in locomotory behavior
Biological Process GO:2000110 negative regulation of macrophage apoptotic process
Biological Process GO:0010700 negative regulation of norepinephrine secretion
Biological Process GO:0042536 negative regulation of tumor necrosis factor biosynthetic process
Biological Process GO:1904468 negative regulation of tumor necrosis factor secretion
Biological Process GO:0032100 positive regulation of appetite
Biological Process GO:1904000 positive regulation of eating behavior
Biological Process GO:0045923 positive regulation of fatty acid metabolic process
Biological Process GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
Biological Process GO:0040018 positive regulation of multicellular organism growth
Biological Process GO:0120058 positive regulation of small intestinal transit
Biological Process GO:1904349 positive regulation of small intestine smooth muscle contraction
Biological Process GO:1903672 positive regulation of sprouting angiogenesis
Biological Process GO:1905564 positive regulation of vascular endothelial cell proliferation
Biological Process GO:1905333 regulation of gastric motility
Biological Process GO:0060123 regulation of growth hormone secretion
Biological Process GO:0043134 regulation of hindgut contraction
Biological Process GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
Biological Process GO:0051963 regulation of synapse assembly
Biological Process GO:0051969 regulation of transmission of nerve impulse
Biological Process GO:0071548 response to dexamethasone
Biological Process GO:0032355 response to estradiol
Biological Process GO:0032354 response to follicle-stimulating hormone
Biological Process GO:0032094 response to food
Biological Process GO:0060416 response to growth hormone
Biological Process GO:0009725 response to hormone
Biological Process GO:1904008 response to monosodium glutamate
Biological Process GO:0007283 spermatogenesis
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0016520 growth hormone-releasing hormone receptor activity
molecular function GO:0001616 growth hormone secretagogue receptor activity
molecular function GO:0042802 identical protein binding
molecular function GO:0017046 peptide hormone binding
cellular component GO:0009986 cell surface
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0016021 integral component of membrane
cellular component GO:0045121 membrane raft
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0098794 postsynapse
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-500792 GPCR ligand binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0001231 BXGD000034 ACTH Syndrome, Ectopic Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003125 BXGD000179 Anorexia Nervosa Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005890 BXGD000345 Body Height
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006370 BXGD000394 Bulimia Pathological Conditions, Signs and Symptoms
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009426 BXGD000609 Combat Disorders Mental Disorders
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0010481 BXGD000673 Cushing Syndrome Endocrine System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012243 BXGD000774 Digestive System Neoplasms Digestive System Diseases; Neoplasms
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013338 BXGD000816 Pituitary dwarfism Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0013473 BXGD000845 Eating Disorders Mental Disorders
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0018553 BXGD001203 Hamartoma Syndrome, Multiple Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020175 BXGD001362 Hunger Behavior and Behavior Mechanisms
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020488 BXGD001402 Hypernatremia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022638 BXGD001567 Ketosis Nutritional and Metabolic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026603 BXGD001907 Motion Sickness Pathological Conditions, Signs and Symptoms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027497 BXGD001993 Nausea Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027662 BXGD002015 Multiple Endocrine Neoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0027830 BXGD002046 neurofibroma Neoplasms; Nervous System Diseases
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028840 BXGD002089 Ocular Hypertension Eye Diseases
C0029095 BXGD002108 Opioid abuse Chemically-Induced Disorders; Mental Disorders
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032897 BXGD002378 Prader-Willi Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034012 BXGD002449 Delayed Puberty Endocrine System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0039585 BXGD002821 Androgen-Insensitivity Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0039590 BXGD002822 Testicular Neoplasms Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0040100 BXGD002840 Thymoma Neoplasms; Hemic and Lymphatic Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0085762 BXGD003251 Alcohol abuse Chemically-Induced Disorders; Mental Disorders
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152020 BXGD003519 Gastroparesis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0162678 BXGD003974 Neurofibromatoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0221406 BXGD004459 Pituitary-dependent Cushing's disease Nervous System Diseases; Endocrine System Diseases
C0232462 BXGD004542 Decrease in appetite Digestive System Diseases; Nervous System Diseases; Mental Disorders
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0242343 BXGD005153 Panhypopituitarism Nervous System Diseases; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0265783 BXGD005575 Congenital hypoplasia of lung Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0271160 BXGD006166 Cortical cataract Eye Diseases
C0271561 BXGD006213 Somatotropin deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280089 BXGD006711 Carcinoid tumor of lung Neoplasms; Respiratory Tract Diseases
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0342442 BXGD007480 ACTH-dependent Cushing's syndrome Endocrine System Diseases
C0342443 BXGD007481 Adrenal Cushing's syndrome Endocrine System Diseases
C0342538 BXGD007498 Constitutional delay of growth and puberty
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346302 BXGD007807 Growth Hormone-Secreting Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0346303 BXGD007808 Thyrotroph adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424678 BXGD008537 Lean body mass
C0426576 BXGD008571 Gastrointestinal symptom Pathological Conditions, Signs and Symptoms
C0432072 BXGD008718 Dysmorphic features
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0489786 BXGD009018 Height
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0541764 BXGD009259 Delayed bone age
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0595921 BXGD009626 Intraocular pressure disorder Eye Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0740392 BXGD009988 Infarction, Middle Cerebral Artery Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751075 BXGD010314 Cancer of Digestive System Digestive System Diseases; Neoplasms
C0855232 BXGD011082 Markedly reduced food intake
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1336746 BXGD012858 Thymic Carcinoid Tumor Neoplasms; Hemic and Lymphatic Diseases
C1391732 BXGD012971 Cancer cachexia
C1397307 BXGD012996 Cardiac fibrosis
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510472 BXGD013170 Drug Dependence Chemically-Induced Disorders; Mental Disorders
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1858656 BXGD015814 Short Stature, Idiopathic, Autosomal Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C1859778 BXGD015931 Postnatal growth retardation
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2267227 BXGD017015 Bulimia Nervosa Mental Disorders
C2362324 BXGD017091 Pediatric Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2717865 BXGD017513 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Immune System Diseases; Cardiovascular Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3495798 BXGD019003 Periodontal inflammation
C3714796 BXGD019434 Isolated somatotropin deficiency
C4072897 BXGD022016 Decreased serum insulin-like growth factor 1
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0039945 [(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)Ethoxy]-5-Hydroxy-2-[[(2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxymethyl]-4-[(2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyloxan-2-Yl]Oxyoxan-3-Yl] (E)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoate 786.26
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein