protein

Showing entry for PR domain zinc finger protein 2

General Target Information
BXGT Id	BXGT022688
Protein Name	PR domain zinc finger protein 2
Uniport Id	Q13029
Gene	PRDM2
Gene Id	7799
Domain	SET; zf-C2H2; zf-C2H2_6
Pfam	PF00856 PF00096
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
1. Metabolism	1.5 Amino acid metabolism	hsa00310	Lysine degradation

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0008340	determination of adult lifespan
Biological Process	GO:0032259	methylation
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0010468	regulation of gene expression
Biological Process	GO:0006355	regulation of transcription, DNA-templated
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
molecular function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function	GO:0003700	DNA-binding transcription factor activity
molecular function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific
molecular function	GO:0008168	methyltransferase activity
molecular function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function	GO:0043565	sequence-specific DNA binding
molecular function	GO:0008270	zinc ion binding
cellular component	GO:0005794	Golgi apparatus
cellular component	GO:0005654	nucleoplasm
cellular component	GO:0005634	nucleus

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001973	BXGD000095	Alcoholic Intoxication, Chronic	Chemically-Induced Disorders; Mental Disorders
C0005684	BXGD000319	Malignant neoplasm of urinary bladder	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695	BXGD000323	Bladder Neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005699	BXGD000325	Blast Phase	Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007097	BXGD000424	Carcinoma	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007103	BXGD000426	Malignant neoplasm of endometrium	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007134	BXGD000443	Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137	BXGD000445	Squamous cell carcinoma	Neoplasms
C0007766	BXGD000478	Intracranial Aneurysm	Nervous System Diseases; Cardiovascular Diseases
C0007847	BXGD000492	Malignant tumor of cervix	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0014859	BXGD000961	Esophageal Neoplasms	Digestive System Diseases; Neoplasms
C0017075	BXGD001089	Ganglioneuroma	Neoplasms
C0017636	BXGD001131	Glioblastoma	Neoplasms
C0017638	BXGD001132	Glioma	Neoplasms
C0023418	BXGD001642	leukemia	Neoplasms
C0023449	BXGD001650	Acute lymphocytic leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452	BXGD001651	Childhood Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467	BXGD001658	Leukemia, Myelocytic, Acute	Neoplasms
C0023473	BXGD001661	Myeloid Leukemia, Chronic	Neoplasms; Hemic and Lymphatic Diseases
C0023903	BXGD001720	Liver neoplasms	Digestive System Diseases; Neoplasms
C0024121	BXGD001735	Lung Neoplasms	Neoplasms; Respiratory Tract Diseases
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0024814	BXGD001809	Marinesco-Sjogren syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0025149	BXGD001826	Medulloblastoma	Neoplasms
C0025202	BXGD001832	melanoma	Neoplasms
C0025286	BXGD001850	Meningioma	Neoplasms; Nervous System Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027708	BXGD002025	Nephroblastoma	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819	BXGD002043	Neuroblastoma	Neoplasms
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028945	BXGD002099	oligodendroglioma	Neoplasms
C0029456	BXGD002157	Osteoporosis	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463	BXGD002160	Osteosarcoma	Neoplasms
C0029925	BXGD002181	Ovarian Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0030421	BXGD002218	Paraganglioma	Neoplasms
C0030521	BXGD002235	Parathyroid Neoplasms	Neoplasms; Endocrine System Diseases
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0031511	BXGD002304	Pheochromocytoma	Neoplasms
C0033375	BXGD002405	Prolactinoma	Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0035335	BXGD002540	Retinoblastoma	Neoplasms; Eye Diseases
C0038356	BXGD002747	Stomach Neoplasms	Digestive System Diseases; Neoplasms
C0040136	BXGD002845	Thyroid Neoplasm	Neoplasms; Endocrine System Diseases
C0079744	BXGD003090	Diffuse Large B-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0086692	BXGD003306	Benign Neoplasm	Neoplasms
C0151468	BXGD003424	Thyroid Gland Follicular Adenoma	Neoplasms; Endocrine System Diseases
C0151779	BXGD003473	Cutaneous Melanoma	Neoplasms; Skin and Connective Tissue Diseases
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0152018	BXGD003518	Esophageal carcinoma	Digestive System Diseases; Neoplasms
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0220668	BXGD004317	Congenital contractural arachnodactyly	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0236733	BXGD004822	Amphetamine-Related Disorders	Chemically-Induced Disorders; Mental Disorders
C0236804	BXGD004835	Amphetamine Addiction	Chemically-Induced Disorders; Mental Disorders
C0236807	BXGD004836	Amphetamine Abuse	Chemically-Induced Disorders; Mental Disorders
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0259785	BXGD005222	Malignant Meningioma	Neoplasms; Nervous System Diseases
C0278510	BXGD006526	Childhood Medulloblastoma	Neoplasms
C0278519	BXGD006531	Recurrent Childhood Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0278876	BXGD006607	Adult Medulloblastoma	Neoplasms
C0278877	BXGD006608	Adult Meningioma	Neoplasms; Nervous System Diseases
C0279626	BXGD006657	Squamous cell carcinoma of esophagus	Digestive System Diseases; Neoplasms
C0279702	BXGD006685	Conventional (Clear Cell) Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280100	BXGD006713	Solid Neoplasm	Neoplasms
C0281784	BXGD006785	Benign Meningioma	Neoplasms; Nervous System Diseases
C0302592	BXGD006851	Cervix carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0424295	BXGD008524	Hyperactive behavior	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0476089	BXGD008977	Endometrial Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0521158	BXGD009130	Recurrent tumor
C0546837	BXGD009343	Malignant neoplasm of esophagus	Digestive System Diseases; Neoplasms
C0549473	BXGD009384	Thyroid carcinoma	Neoplasms; Endocrine System Diseases
C0585442	BXGD009593	Osteosarcoma of bone	Neoplasms
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766	BXGD009669	Leukemogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0700095	BXGD009875	Central neuroblastoma	Neoplasms; Nervous System Diseases
C0750974	BXGD010270	Brain Tumor, Primary	Neoplasms; Nervous System Diseases
C0751396	BXGD010425	Well Differentiated Oligodendroglioma	Neoplasms
C0751606	BXGD010523	Adult Acute Lymphocytic Leukemia
C1140680	BXGD011718	Malignant neoplasm of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955	BXGD012005	Tumor Cell Invasion
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1314691	BXGD012388	Age at menarche	Behavior and Behavior Mechanisms
C1332977	BXGD012569	Childhood Leukemia	Neoplasms
C1332986	BXGD012574	Childhood Osteosarcoma	Neoplasms
C1333015	BXGD012581	Childhood Kidney Wilms Tumor	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1335113	BXGD012762	Opisthorchis Viverrini-Related Cholangiocarcinoma	Neoplasms
C1621958	BXGD013468	Glioblastoma Multiforme	Neoplasms
C1739405	BXGD013740	CML progression
C1762616	BXGD013753	Meningioma, benign, no ICD-O subtype	Neoplasms; Nervous System Diseases
C1861848	BXGD016082	PARAGANGLIOMAS 4	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2347761	BXGD017049	Childhood Myelodysplastic Syndrome	Hemic and Lymphatic Diseases
C2363142	BXGD017096	T-Cell Prolymphocytic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2825306	BXGD017772	Treatment related leukaemia	Neoplasms
C2931822	BXGD018068	Nasopharyngeal carcinoma	Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939419	BXGD018178	Secondary Neoplasm	Pathological Conditions, Signs and Symptoms; Neoplasms
C3463824	BXGD018899	MYELODYSPLASTIC SYNDROME	Hemic and Lymphatic Diseases
C3900098	BXGD020106	Adult Myelodysplastic Syndrome	Hemic and Lymphatic Diseases
C4048328	BXGD021903	cervical cancer	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165	BXGD022126	Childhood Neuroblastoma	Neoplasms
C4511452	BXGD023002	Sporadic Parkinson disease	Nervous System Diseases
C4523846	BXGD023079	MSI-high
C4551683	BXGD023389	Adrenal Gland Pheochromocytoma	Neoplasms; Endocrine System Diseases
C4721610	BXGD023760	Carcinoma, Ovarian Epithelial	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0006186	L-Aspartic acid		133.1

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}