Showing entry for Granulocyte-macrophage colony-stimulating factor receptor subunit alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022826
Protein NameGranulocyte-macrophage colony-stimulating factor receptor subunit alpha
Uniport IdP15509
GeneCSF2RA
Gene Id1438
DomainIL3Ra_N; IL6Ra-bind
Pfam PF18611   PF09240  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.2 Signal transduction hsa04630 Jak-STAT signaling pathway
5. Organismal Systems 5.1 Immune system hsa04640 Hematopoietic cell lineage
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0000165 MAPK cascade
molecular function GO:0019955 cytokine binding
molecular function GO:0004896 cytokine receptor activity
molecular function GO:0038023 signaling receptor activity
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005576 extracellular region
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins
R-HSA-449147 Signaling by Interleukins
R-HSA-451927 Interleukin-2 family signaling
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5668914 Diseases of metabolism
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5683826 Surfactant metabolism
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5687613 Diseases associated with surfactant metabolism
R-HSA-5688849 Defective CSF2RB causes SMDP5
R-HSA-5688890 Defective CSF2RA causes SMDP4
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-9607240 FLT3 Signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012546 BXGD000776 Diphtheria Infections
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0020517 BXGD001415 Hypersensitivity Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0026499 BXGD001905 Monosomy Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030421 BXGD002218 Paraganglioma Neoplasms
C0034050 BXGD002452 Pulmonary Alveolar Proteinosis Respiratory Tract Diseases
C0034642 BXGD002485 Rales Pathological Conditions, Signs and Symptoms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0039231 BXGD002799 Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0039538 BXGD002819 Teratoma Neoplasms
C0041408 BXGD002923 Turner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0155880 BXGD003831 Intrinsic asthma Respiratory Tract Diseases; Immune System Diseases
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0231835 BXGD004527 Tachypnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0340194 BXGD007308 Respiratory failure without hypercapnia Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0349639 BXGD007943 Juvenile Myelomonocytic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0700292 BXGD009884 Hypoxemia Pathological Conditions, Signs and Symptoms
C1261473 BXGD011855 Sarcoma Neoplasms
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1827849 BXGD013780 IgE-mediated allergic asthma Immune System Diseases
C1839130 BXGD014358 Dystonia 3, Torsion, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1867873 BXGD016473 Failure to thrive in infancy
C2677877 BXGD017390 Surfactant Metabolism Dysfunction, Pulmonary, 4 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C2931035 BXGD017942 Pulmonary alveolar proteinosis, congenital Respiratory Tract Diseases
C3277226 BXGD018711 Restrictive ventilatory defect
C4022660 BXGD020947 Autoimmune antibody positivity
C4023112 BXGD021110 Acute infectious pneumonia
C4025279 BXGD021620 Respiratory failure requiring assisted ventilation Respiratory Tract Diseases
C4281786 BXGD022416 Presence of foam cells Cardiovascular Diseases
C4476749 BXGD022860 Crazy paving pattern on pulmonary HRCT
C4476917 BXGD022889 Elevated carcinoembryonic antigen level
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein