protein

Showing entry for Telomerase-binding protein EST1A

General Target Information
BXGT Id	BXGT022850
Protein Name	Telomerase-binding protein EST1A
Uniport Id	Q86US8
Gene	SMG6
Gene Id	23293
Domain	EST1; EST1_DNA_bind; PIN_4
Pfam	PF10374 PF10373 PF13638
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
2. Genetic Information Processing	2.2 Translation	hsa03015	mRNA surveillance pathway

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0006406	mRNA export from nucleus
Biological Process	GO:1904354	negative regulation of telomere capping
Biological Process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process	GO:0035303	regulation of dephosphorylation
Biological Process	GO:0051972	regulation of telomerase activity
Biological Process	GO:0032204	regulation of telomere maintenance
Biological Process	GO:0032210	regulation of telomere maintenance via telomerase
Biological Process	GO:0007004	telomere maintenance via telomerase
molecular function	GO:0070182	DNA polymerase binding
molecular function	GO:0004521	endoribonuclease activity
molecular function	GO:0046872	metal ion binding
molecular function	GO:0043021	ribonucleoprotein complex binding
molecular function	GO:0003723	RNA binding
molecular function	GO:0070034	telomerase RNA binding
molecular function	GO:0042162	telomeric DNA binding
cellular component	GO:0000781	chromosome, telomeric region
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005829	cytosol
cellular component	GO:0005730	nucleolus
cellular component	GO:0005634	nucleus
cellular component	GO:0005697	telomerase holoenzyme complex

Reactome

Pathway Id	Pathway Name
R-HSA-8953854	Metabolism of RNA
R-HSA-927802	Nonsense-Mediated Decay (NMD)
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0005890	BXGD000345	Body Height
C0005938	BXGD000351	Bone Density
C0007137	BXGD000445	Squamous cell carcinoma	Neoplasms
C0010068	BXGD000648	Coronary heart disease	Cardiovascular Diseases
C0013595	BXGD000858	Eczema	Skin and Connective Tissue Diseases
C0014544	BXGD000926	Epilepsy	Nervous System Diseases
C0014556	BXGD000932	Epilepsy, Temporal Lobe	Nervous System Diseases
C0014859	BXGD000961	Esophageal Neoplasms	Digestive System Diseases; Neoplasms
C0017654	BXGD001136	Glomerular Filtration Rate
C0023508	BXGD001675	White Blood Cell Count procedure
C0026267	BXGD001896	Mitral Valve Prolapse Syndrome	Cardiovascular Diseases
C0027651	BXGD002009	Neoplasms	Neoplasms
C0032181	BXGD002332	Platelet Count measurement
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0037369	BXGD002691	Smoking	Behavior and Behavior Mechanisms
C0040420	BXGD002861	Tonometry
C0042834	BXGD003004	Vital capacity
C0177804	BXGD004019	Bone Mineral Density Test
C0200637	BXGD004042	Monocyte count procedure
C0201512	BXGD004048	Thyroglobulin antibody measurement
C0205682	BXGD004105	Waist-Hip Ratio
C0266463	BXGD005675	Lissencephaly	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0409959	BXGD008400	Osteoarthritis, Knee	Musculoskeletal Diseases
C0750880	BXGD010239	Monocyte count result
C0871470	BXGD011316	Systolic Pressure
C1305855	BXGD012348	Body mass index
C1842247	BXGD014508	CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1861172	BXGD016016	Venous Thromboembolism	Cardiovascular Diseases
C1956346	BXGD016627	Coronary Artery Disease	Cardiovascular Diseases
C3160814	BXGD018477	Cannabis use
C4317109	BXGD022725	Epileptic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000436	Glycerol		92.09

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}