Showing entry for Retinoblastoma-binding protein 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022877
Protein NameRetinoblastoma-binding protein 5
Uniport IdQ15291
GeneRBBP5
Gene Id5929
DomainWD40
Pfam PF00400  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1904837 beta-catenin-TCF complex assembly
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0051568 histone H3-K4 methylation
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0045652 regulation of megakaryocyte differentiation
Biological Process GO:0043627 response to estrogen
molecular function GO:0035064 methylated histone binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
cellular component GO:0035097 histone methyltransferase complex
cellular component GO:0071339 MLL1 complex
cellular component GO:0044666 MLL3/4 complex
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0048188 Set1C/COMPASS complex
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-162582 Signal Transduction
R-HSA-195721 Signaling by WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-212436 Generic Transcription Pathway
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-392499 Metabolism of proteins
R-HSA-4839726 Chromatin organization
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-597592 Post-translational protein modification
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8951664 Neddylation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein