Showing entry for Sorting nexin-3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023036
Protein NameSorting nexin-3
Uniport IdO60493
GeneSNX3
Gene Id8724
DomainPX
Pfam PF00787  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032456 endocytic recycling
Biological Process GO:0070676 intralumenal vesicle formation
Biological Process GO:0034499 late endosome to Golgi transport
Biological Process GO:0010324 membrane invagination
Biological Process GO:2000642 negative regulation of early endosome to late endosome transport
Biological Process GO:0050765 negative regulation of phagocytosis
Biological Process GO:0042177 negative regulation of protein catabolic process
Biological Process GO:0051224 negative regulation of protein transport
Biological Process GO:0046597 negative regulation of viral entry into host cell
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0022615 protein to membrane docking
Biological Process GO:0015031 protein transport
Biological Process GO:0033157 regulation of intracellular protein transport
Biological Process GO:0030111 regulation of Wnt signaling pathway
Biological Process GO:0009617 response to bacterium
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
molecular function GO:0032266 phosphatidylinositol-3-phosphate binding
molecular function GO:0070273 phosphatidylinositol-4-phosphate binding
molecular function GO:0010314 phosphatidylinositol-5-phosphate binding
molecular function GO:0019903 protein phosphatase binding
cellular component GO:0030136 clathrin-coated vesicle
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005769 early endosome
cellular component GO:0031901 early endosome membrane
cellular component GO:0032009 early phagosome
cellular component GO:0010008 endosome membrane
cellular component GO:0070062 extracellular exosome
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-195721 Signaling by WNT
R-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-392499 Metabolism of proteins
R-HSA-5688426 Deubiquitination
R-HSA-5689880 Ub-specific processing proteases
R-HSA-597592 Post-translational protein modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033324 BXGD002404 Prognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0265554 BXGD005548 Ectrodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1832440 BXGD013843 MICROPHTHALMIA, SYNDROMIC 8 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C2699510 BXGD017460 Split-Hand/Foot Malformation Pathological Conditions, Signs and Symptoms
C2931019 BXGD017938 Split hand foot deformity 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein