Showing entry for OTU domain-containing protein 7B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023186
Protein NameOTU domain-containing protein 7B
Uniport IdQ6GQQ9
GeneOTUD7B
Gene Id56957
DomainOTU; UBA_4; zf-A20
Pfam PF02338   PF01754  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0002385 mucosal immune response
Biological Process GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0032717 negative regulation of interleukin-8 production
Biological Process GO:1900181 negative regulation of protein localization to nucleus
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process
Biological Process GO:0035871 protein K11-linked deubiquitination
Biological Process GO:0071108 protein K48-linked deubiquitination
Biological Process GO:0070536 protein K63-linked deubiquitination
molecular function GO:0008234 cysteine-type peptidase activity
molecular function GO:0003677 DNA binding
molecular function GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
molecular function GO:1990380 Lys48-specific deubiquitinase activity
molecular function GO:0004843 thiol-dependent ubiquitin-specific protease activity
molecular function GO:0036459 thiol-dependent ubiquitinyl hydrolase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-392499 Metabolism of proteins
R-HSA-5357786 TNFR1-induced proapoptotic signaling
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5688426 Deubiquitination
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-597592 Post-translational protein modification
R-HSA-73887 Death Receptor Signalling
R-HSA-75893 TNF signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0005890 BXGD000345 Body Height
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein