protein

Showing entry for Transcription elongation factor SPT5

General Target Information
BXGT Id	BXGT023307
Protein Name	Transcription elongation factor SPT5
Uniport Id	O00267
Gene	SUPT5H
Gene Id	6829
Domain	KOW; Spt5-NGN; Spt5_N
Pfam	PF00467 PF03439 PF11942
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0006370	7-methylguanosine mRNA capping
Biological Process	GO:0032785	negative regulation of DNA-templated transcription, elongation
Biological Process	GO:1900364	negative regulation of mRNA polyadenylation
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0032786	positive regulation of DNA-templated transcription, elongation
Biological Process	GO:0016239	positive regulation of macroautophagy
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0050434	positive regulation of viral transcription
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0006366	transcription by RNA polymerase II
Biological Process	GO:0006368	transcription elongation from RNA polymerase II promoter
molecular function	GO:0003682	chromatin binding
molecular function	GO:0019899	enzyme binding
molecular function	GO:0003729	mRNA binding
molecular function	GO:0046982	protein heterodimerization activity
molecular function	GO:0003723	RNA binding
cellular component	GO:0032044	DSIF complex
cellular component	GO:0005654	nucleoplasm
cellular component	GO:0005634	nucleus

Reactome

Pathway Id	Pathway Name
R-HSA-112382	Formation of RNA Pol II elongation complex
R-HSA-113418	Formation of the Early Elongation Complex
R-HSA-162587	HIV Life Cycle
R-HSA-162587	HIV Life Cycle
R-HSA-162599	Late Phase of HIV Life Cycle
R-HSA-162599	Late Phase of HIV Life Cycle
R-HSA-162906	HIV Infection
R-HSA-162906	HIV Infection
R-HSA-1643685	Disease
R-HSA-1643685	Disease
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-167169	HIV Transcription Elongation
R-HSA-167169	HIV Transcription Elongation
R-HSA-167172	Transcription of the HIV genome
R-HSA-167172	Transcription of the HIV genome
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167242	Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287	HIV elongation arrest and recovery
R-HSA-167290	Pausing and recovery of HIV elongation
R-HSA-212436	Generic Transcription Pathway
R-HSA-3700989	Transcriptional Regulation by TP53
R-HSA-5663205	Infectious disease
R-HSA-5663205	Infectious disease
R-HSA-674695	RNA Polymerase II Pre-transcription Events
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6807505	RNA polymerase II transcribes snRNA genes
R-HSA-72086	mRNA Capping
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)
R-HSA-75955	RNA Polymerase II Transcription Elongation
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-8953854	Metabolism of RNA

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0019348	BXGD001325	Herpes Simplex Infections	Infections; Skin and Connective Tissue Diseases
C0023508	BXGD001675	White Blood Cell Count procedure
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0200638	BXGD004043	Eosinophil count procedure
C0524851	BXGD009246	Neurodegenerative Disorders	Nervous System Diseases
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000436	Glycerol		92.09
BXGC0003705	Chloride		35.45

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}