Showing entry for T-cell surface glycoprotein CD3 epsilon chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023327
Protein NameT-cell surface glycoprotein CD3 epsilon chain
Uniport IdP07766
GeneCD3E
Gene Id916
DomainIg_5; ITAM
Pfam PF02189  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04640 Hematopoietic cell lineage
5. Organismal Systems 5.1 Immune system hsa04658 Th1 and Th2 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04659 Th17 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05142 Chagas disease (American trypanosomiasis)
6. Human Diseases 6.9 Infectious diseases: Viral hsa05162 Measles
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05170 Human immunodeficiency virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
6. Human Diseases 6.3 Immune diseases hsa05340 Primary immunodeficiency
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0097190 apoptotic signaling pathway
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0021549 cerebellum development
Biological Process GO:0016358 dendrite development
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0045879 negative regulation of smoothened signaling pathway
Biological Process GO:0045060 negative thymic T cell selection
Biological Process GO:0046641 positive regulation of alpha-beta T cell proliferation
Biological Process GO:0050850 positive regulation of calcium-mediated signaling
Biological Process GO:0033634 positive regulation of cell-cell adhesion mediated by integrin
Biological Process GO:0001954 positive regulation of cell-matrix adhesion
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0032729 positive regulation of interferon-gamma production
Biological Process GO:0032743 positive regulation of interleukin-2 production
Biological Process GO:0032753 positive regulation of interleukin-4 production
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0002669 positive regulation of T cell anergy
Biological Process GO:0042102 positive regulation of T cell proliferation
Biological Process GO:0045059 positive thymic T cell selection
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0050776 regulation of immune response
Biological Process GO:0007584 response to nutrient
Biological Process GO:0007172 signal complex assembly
Biological Process GO:0042110 T cell activation
Biological Process GO:0031295 T cell costimulation
Biological Process GO:0030217 T cell differentiation
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0042802 identical protein binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0017124 SH3 domain binding
molecular function GO:0030159 signaling receptor complex adaptor activity
molecular function GO:0042608 T cell receptor binding
molecular function GO:0004888 transmembrane signaling receptor activity
cellular component GO:0042105 alpha-beta T cell receptor complex
cellular component GO:0044297 cell body
cellular component GO:0005911 cell-cell junction
cellular component GO:0043197 dendritic spine
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0001772 immunological synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0042101 T cell receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389948 PD-1 signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003257 BXGD000189 Antibody Deficiency Syndrome Immune System Diseases
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0011606 BXGD000735 Exfoliative dermatitis Skin and Connective Tissue Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019214 BXGD001307 Hepatosplenomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Hemic and Lymphatic Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024307 BXGD001765 Lymphomatoid Granulomatosis Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029882 BXGD002177 Otitis Media Otorhinolaryngologic Diseases
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0035288 BXGD002524 Reticuloendotheliosis, X-linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0151669 BXGD003457 Increased antibody level in blood
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0242583 BXGD005178 Bare Lymphocyte Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0279583 BXGD006640 Childhood T Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0473133 BXGD008932 Protracted diarrhea Pathological Conditions, Signs and Symptoms
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0694550 BXGD009852 Recurrent pneumonia Infections; Respiratory Tract Diseases
C0747085 BXGD010158 Recurrent otitis media Otorhinolaryngologic Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1263762 BXGD011896 Endocervical adenocarcinoma
C1274233 BXGD012028 T-lymphocyte immunodeficiency Immune System Diseases
C1299237 BXGD012253 Endocervical Carcinoma
C1334274 BXGD012695 Invasive Carcinoma Neoplasms
C1832323 BXGD013827 Failure to thrive secondary to recurrent infections
C1845609 BXGD014755 Lymphoid depletion
C1860128 BXGD015957 Recurrent candida infections
C1861284 BXGD016025 Immunodeficiency due to Defect in CD3-Epsilon Immune System Diseases
C1861403 BXGD016045 Variable expressivity
C1955906 BXGD016613 Lymphoma, Extranodal NK-T-Cell Neoplasms
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2700553 BXGD017472 Omenn Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C3179349 BXGD018550 Gastrointestinal Stromal Sarcoma Digestive System Diseases; Neoplasms
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C3808828 BXGD019554 Recurrent gastroenteritis
C3810127 BXGD019639 IMMUNODEFICIENCY 18
C3810128 BXGD019640 IMMUNODEFICIENCY 18, SEVERE COMBINED IMMUNODEFICIENCY VARIANT
C3810129 BXGD019641 IMMUNODEFICIENCY 18, SCID VARIANT
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C4024599 BXGD021333 Chronic oral candidiasis Infections; Skin and Connective Tissue Diseases
C4025684 BXGD021733 Recurrent abscess formation
C4477053 BXGD022911 Decreased proportion of CD3-positive T cells Immune System Diseases; Hemic and Lymphatic Diseases
C4531166 BXGD023200 Decreased lymphocyte proliferation in response to mitogen
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004275 Acetaldehyde 44.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein