Showing entry for KN motif and ankyrin repeat domain-containing protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023543
Protein NameKN motif and ankyrin repeat domain-containing protein 1
Uniport IdQ14678
GeneKANK1
Gene Id23189
DomainAnk; KN_motif
Pfam PF12796   PF12075  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0090521 glomerular visceral epithelial cell migration
Biological Process GO:0030837 negative regulation of actin filament polymerization
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0046627 negative regulation of insulin receptor signaling pathway
Biological Process GO:2000393 negative regulation of lamellipodium morphogenesis
Biological Process GO:0010977 negative regulation of neuron projection development
Biological Process GO:0035024 negative regulation of Rho protein signal transduction
Biological Process GO:1900028 negative regulation of ruffle assembly
Biological Process GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0030177 positive regulation of Wnt signaling pathway
Biological Process GO:0090303 positive regulation of wound healing
Biological Process GO:2000114 regulation of establishment of cell polarity
Biological Process GO:0035023 regulation of Rho protein signal transduction
molecular function GO:0008013 beta-catenin binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005856 cytoskeleton
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0032587 ruffle membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-8939211 ESR-mediated signaling
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-9671555 Signaling by PDGFR in disease
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007117 BXGD000433 Basal cell carcinoma Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027830 BXGD002046 neurofibroma Neoplasms; Nervous System Diseases
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0032463 BXGD002357 Polycythemia Vera Neoplasms; Hemic and Lymphatic Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0202098 BXGD004070 Insulin measurement
C0206710 BXGD004258 Basal Cell Neoplasm Neoplasms
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0426970 BXGD008598 Spastic Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0428568 BXGD008633 Fasting blood glucose measurement
C0553767 BXGD009419 Congenital Cerebral Palsy Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751676 BXGD010549 Basal Cell Cancer Neoplasms
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0836924 BXGD010864 Thrombocytosis Hemic and Lymphatic Diseases
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1302995 BXGD012316 Congenital Fibrosis of the Extraocular Muscles Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1611743 BXGD013456 Familial (FPAH)
C2242776 BXGD017001 Plexiform leiomyoma
C2751938 BXGD017750 Cerebral Palsy, Spastic Quadriplegic, 1 Nervous System Diseases
C2752061 BXGD017763 Cerebral Palsy, Spastic Quadriplegic, 2 Nervous System Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3665419 BXGD019285 intracranial glioma Neoplasms; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021085 BXGD020544 Abnormality of brain morphology
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein