Showing entry for Spastin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023601
Protein NameSpastin
Uniport IdQ9UBP0
GeneSPAST
Gene Id6683
DomainA; A_lid_3; Vps4_C
Pfam PF00004   PF17862   PF09336  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008089 anterograde axonal transport
Biological Process GO:0019896 axonal transport of mitochondrion
Biological Process GO:0007409 axonogenesis
Biological Process GO:0032506 cytokinetic process
Biological Process GO:0031122 cytoplasmic microtubule organization
Biological Process GO:0061640 cytoskeleton-dependent cytokinesis
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0010458 exit from mitosis
Biological Process GO:0090148 membrane fission
Biological Process GO:0008152 metabolic process
Biological Process GO:0001578 microtubule bundle formation
Biological Process GO:0051013 microtubule severing
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0051228 mitotic spindle disassembly
Biological Process GO:0031468 nuclear envelope reassembly
Biological Process GO:0032467 positive regulation of cytokinesis
Biological Process GO:0031117 positive regulation of microtubule depolymerization
Biological Process GO:0034214 protein hexamerization
Biological Process GO:0051260 protein homooligomerization
molecular function GO:0043014 alpha-tubulin binding
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0048487 beta-tubulin binding
molecular function GO:0016853 isomerase activity
molecular function GO:0008017 microtubule binding
molecular function GO:0008568 microtubule-severing ATPase activity
molecular function GO:0044877 protein-containing complex binding
cellular component GO:1904115 axon cytoplasm
cellular component GO:0005813 centrosome
cellular component GO:0005737 cytoplasm
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0071782 endoplasmic reticulum tubular network
cellular component GO:0005768 endosome
cellular component GO:0070062 extracellular exosome
cellular component GO:0016021 integral component of membrane
cellular component GO:0005811 lipid droplet
cellular component GO:0005874 microtubule
cellular component GO:0030496 midbody
cellular component GO:0031965 nuclear membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005819 spindle
Reactome
Pathway Id Pathway Name
R-HSA-1640170 Cell Cycle
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2995410 Nuclear Envelope (NE) Reassembly
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0023882 BXGD001710 Little's Disease Nervous System Diseases
C0024031 BXGD001727 Low Back Pain Pathological Conditions, Signs and Symptoms
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0030360 BXGD002215 Papillon-Lefevre Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0030486 BXGD002229 Paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0034152 BXGD002467 Henoch-Schoenlein Purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0034935 BXGD002497 Babinski Reflex
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037771 BXGD002702 Paraparesis, Spastic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037772 BXGD002703 Spastic Paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037773 BXGD002704 Spastic Paraplegia, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042024 BXGD002949 Urinary Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0078981 BXGD003059 Arachnoid Cysts Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0085606 BXGD003201 Urgency of micturition Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085632 BXGD003215 Apathy Behavior and Behavior Mechanisms
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0154682 BXGD003731 Lateral Sclerosis Nervous System Diseases
C0175693 BXGD004001 Russell-Silver syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0201657 BXGD004051 C-reactive protein measurement
C0221166 BXGD004397 Paraparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231687 BXGD004509 Spastic gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234410 BXGD004665 Physiologic disinhibition
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0238651 BXGD004951 Ankle clonus
C0239067 BXGD004961 Difficulty walking up stairs Pathological Conditions, Signs and Symptoms
C0271682 BXGD006233 Mixed sensory-motor polyneuropathy Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0393555 BXGD008088 Pure hereditary spastic paraplegia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0424296 BXGD008525 Social disinhibition Mental Disorders
C0431369 BXGD008674 Dysgenesis of corpus callosum
C0431388 BXGD008682 Microdysgenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0443306 BXGD008817 Spastic Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0495694 BXGD009037 Dysarthria and anarthria
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0751602 BXGD010520 Hereditary Autosomal Dominant Spastic Paraplegia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0854193 BXGD011005 Cognitive deterioration
C0917816 BXGD011419 Mental deficiency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1271100 BXGD012007 Lower limb spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1285162 BXGD012167 Degenerative disorder Pathological Conditions, Signs and Symptoms
C1334804 BXGD012740 Motor Manifestations Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1392786 BXGD012978 Cognitive changes Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1578482 BXGD013427 Valgus deformities of feet Musculoskeletal Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1836296 BXGD014105 Muscle Weakness Lower Limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836450 BXGD014117 Distal lower limb muscle weakness
C1838192 BXGD014302 SPASTIC PARAPLEGIA 6, AUTOSOMAL DOMINANT (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1842364 BXGD014511 Central hypotonia
C1843013 BXGD014549 Alzheimer disease, familial, type 3 Nervous System Diseases; Mental Disorders
C1843175 BXGD014563 Hyperreflexia in upper limbs Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1843570 BXGD014595 Tip-toe gait
C1843663 BXGD014600 Urinary bladder sphincter dysfunction
C1846566 BXGD014829 Degeneration of the lateral corticospinal tracts
C1848736 BXGD014970 Distal amyotrophy
C1849128 BXGD015009 Spastic paraplegia 15, autosomal recessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1849134 BXGD015010 Impaired vibration sensation in the lower limbs
C1853247 BXGD015324 SPASTIC PARAPLEGIA 31, AUTOSOMAL DOMINANT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1854372 BXGD015395 Impaired vibration sensation at ankles
C1857704 BXGD015741 Abnormal myelination
C1858712 BXGD015821 Spastic paraplegia 10, autosomal dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1861305 BXGD016027 TARSAL-CARPAL COALITION SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1861403 BXGD016045 Variable expressivity
C1863704 BXGD016189 Spastic paraplegia 8, autosomal dominant Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1866010 BXGD016360 Proximal muscle weakness in lower limbs
C1866855 BXGD016426 Spastic paraplegia 4, autosomal dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1963060 BXGD016679 Agitation, CTCAE 3.0
C1963167 BXGD016686 Memory Impairment, CTCAE 3.0
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2673700 BXGD017223 Brisk reflexes Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2697766 BXGD017436 Interleukin 18 Measurement
C2931276 BXGD017994 Spastic paraplegia 17 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2931355 BXGD018006 Spastic paraplegia 3, autosomal dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2931441 BXGD018022 Hereditary spastic paralysis, infantile onset ascending Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3711371 BXGD019381 Spastic Paraplegia Type 4 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4016882 BXGD020384 SPASTIC PARAPLEGIA 4, MODIFIER OF
C4022739 BXGD020975 Abnormal neuron morphology
C4024610 BXGD021341 Leg muscle stiffness
C4025360 BXGD021652 Functional motor deficit
C4268744 BXGD022328 Atypical femoral fracture
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
C4552855 BXGD023528 Agitation, CTCAE 5.0
C4553743 BXGD023548 Spasticity, CTCAE
C4553765 BXGD023551 Memory Impairment, CTCAE 5.0
C4553976 BXGD023554 Urinary Urgency, CTCAE 5
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein