Showing entry for Sarcoplasmic/endoplasmic reticulum calcium ATPase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023653
Protein NameSarcoplasmic/endoplasmic reticulum calcium ATPase 2
Uniport IdP16615
GeneATP2A2
Gene Id488
DomainCation_ATPase; Cation_ATPase_C; Cation_ATPase_N; E1-E2_ATPase
Pfam PF00689   PF00690  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1990036 calcium ion import into sarcoplasmic reticulum
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:1903515 calcium ion transport from cytosol to endoplasmic reticulum
Biological Process GO:0014898 cardiac muscle hypertrophy in response to stress
Biological Process GO:0007155 cell adhesion
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0034605 cellular response to heat
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0032469 endoplasmic reticulum calcium ion homeostasis
Biological Process GO:0008544 epidermis development
Biological Process GO:0006984 ER-nucleus signaling pathway
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0045822 negative regulation of heart contraction
Biological Process GO:1900121 negative regulation of receptor binding
Biological Process GO:0006996 organelle organization
Biological Process GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration
Biological Process GO:0010460 positive regulation of heart rate
Biological Process GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction
Biological Process GO:0086036 regulation of cardiac muscle cell membrane potential
Biological Process GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
Biological Process GO:0002026 regulation of the force of heart contraction
Biological Process GO:0055119 relaxation of cardiac muscle
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0070296 sarcoplasmic reticulum calcium ion transport
Biological Process GO:0003009 skeletal muscle contraction
Biological Process GO:0014883 transition between fast and slow fiber
Biological Process GO:0033292 T-tubule organization
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0005388 calcium transmembrane transporter activity, phosphorylative mechanism
molecular function GO:0086039 calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
molecular function GO:0019899 enzyme binding
molecular function GO:0044325 ion channel binding
molecular function GO:0031775 lutropin-choriogonadotropic hormone receptor binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0008553 proton-exporting ATPase activity, phosphorylative mechanism
molecular function GO:0044548 S100 protein binding
cellular component GO:0061831 apical ectoplasmic specialization
cellular component GO:0090534 calcium ion-transporting ATPase complex
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0014801 longitudinal sarcoplasmic reticulum
cellular component GO:0016020 membrane
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0120025 plasma membrane bounded cell projection
cellular component GO:0031095 platelet dense tubular network membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0097470 ribbon synapse
cellular component GO:0016529 sarcoplasmic reticulum
cellular component GO:0033017 sarcoplasmic reticulum membrane
cellular component GO:0012506 vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-1912420 Pre-NOTCH Processing in Golgi
R-HSA-1912422 Pre-NOTCH Expression and Processing
R-HSA-382551 Transport of small molecules
R-HSA-397014 Muscle contraction
R-HSA-418346 Platelet homeostasis
R-HSA-418359 Reduction of cytosolic Ca++ levels
R-HSA-418360 Platelet calcium homeostasis
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000887 BXGD000017 Acantholysis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0001202 BXGD000032 Acrokeratosis Skin and Connective Tissue Diseases
C0002152 BXGD000104 Alloxan Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003076 BXGD000171 Aniridia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005937 BXGD000350 Bone Cysts Neoplasms; Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013264 BXGD000808 Muscular Dystrophy, Duchenne Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0015190 BXGD000968 Euthyroid Sick Syndromes Endocrine System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0022595 BXGD001562 Keratosis Follicularis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0023827 BXGD001707 liposarcoma Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027962 BXGD002064 Melanocytic nevus Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030436 BXGD002221 Parakeratosis Skin and Connective Tissue Diseases
C0033774 BXGD002419 Pruritus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0037277 BXGD002677 Skin Diseases, Genetic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038433 BXGD002754 Streptozotocin Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0039585 BXGD002821 Androgen-Insensitivity Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0043207 BXGD003038 Wolfram Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Male Urogenital Diseases; Nervous System Diseases; Endocrine System Diseases; Otorhinolaryngologic Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085106 BXGD003124 Familial benign pemphigus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202236 BXGD004086 Triglycerides measurement
C0206145 BXGD004163 Stunned Myocardium Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0206146 BXGD004164 Myocardial Stunning Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0206720 BXGD004266 Squamous Cell Neoplasms Neoplasms
C0220641 BXGD004305 Lip and Oral Cavity Carcinoma Neoplasms; Stomatognathic Diseases
C0221270 BXGD004430 Acanthosis Pathological Conditions, Signs and Symptoms
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0234958 BXGD004702 Muscle degeneration Musculoskeletal Diseases
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0236773 BXGD004827 Depressed bipolar I disorder Mental Disorders
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242698 BXGD005189 Ventricular Dysfunction, Left Cardiovascular Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0264716 BXGD005417 Chronic heart failure Cardiovascular Diseases
C0265971 BXGD005594 Acrokeratosis Verruciformis of Hopf Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0270823 BXGD006112 Petit mal status Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278608 BXGD006549 Adult Liposarcoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279984 BXGD006703 Childhood Liposarcoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280483 BXGD006750 Adult Anaplastic Astrocytoma Neoplasms
C0280785 BXGD006760 Diffuse Astrocytoma Neoplasms
C0282193 BXGD006798 Iron Overload Nutritional and Metabolic Diseases
C0311335 BXGD006877 Grand Mal Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0334579 BXGD007120 Anaplastic astrocytoma Neoplasms
C0340970 BXGD007379 Congenital neutropenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0341047 BXGD007386 Hypertrophy of parotid gland Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Stomatognathic Diseases
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0349782 BXGD007954 Ischemic cardiomyopathy Cardiovascular Diseases
C0376416 BXGD007997 Hibernation, Myocardial Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0393734 BXGD008131 Complex Partial Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0423776 BXGD008508 Palmar pit
C0423820 BXGD008514 Ridged nails
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0429028 BXGD008646 QT interval feature (observable entity)
C0473575 BXGD008942 Acantholytic Dyskeratotic Epidermal Nevus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751522 BXGD010488 Status Epilepticus, Subclinical Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751523 BXGD010489 Non-Convulsive Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751524 BXGD010490 Simple Partial Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751688 BXGD010551 Malignant Squamous Cell Neoplasm Neoplasms
C0853897 BXGD010985 Diabetic Cardiomyopathies Endocrine System Diseases; Cardiovascular Diseases
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0948201 BXGD011515 Alloimmunisation
C0949658 BXGD011582 Cardiomyopathy, Hypertrophic, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1135196 BXGD011694 Heart Failure, Diastolic Cardiovascular Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332200 BXGD012501 Adult Diffuse Astrocytoma Neoplasms
C1383860 BXGD012935 Cardiac Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1839839 BXGD014416 MAJOR AFFECTIVE DISORDER 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C1842774 BXGD014536 Hypermelanotic macule
C1844632 BXGD014654 Anal mucosal leukoplakia
C1852197 BXGD015264 MAJOR AFFECTIVE DISORDER 1 Mental Disorders
C1852296 BXGD015271 Darier Disease, Acral Hemorrhagic Type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1852297 BXGD015272 Darier Disease, Segmental Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1852301 BXGD015273 Plantar pits
C1852311 BXGD015274 Subungual hyperkeratotic fragments
C1853118 BXGD015302 Severe congenital neutropenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1868938 BXGD016542 End stage cardiac failure
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C1970943 BXGD016852 MAJOR AFFECTIVE DISORDER 4 Mental Disorders
C1970945 BXGD016853 MAJOR AFFECTIVE DISORDER 6 Mental Disorders
C2700438 BXGD017469 MAJOR AFFECTIVE DISORDER 7 Mental Disorders
C2700439 BXGD017470 MAJOR AFFECTIVE DISORDER 8 Mental Disorders
C2700440 BXGD017471 MAJOR AFFECTIVE DISORDER 9 Mental Disorders
C2936346 BXGD018108 22q11 Deletion Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C3250443 BXGD018584 MYOTONIC DYSTROPHY 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3814530 BXGD019668 Skin Vesicle Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C3899668 BXGD020097 Childhood Diffuse Astrocytoma Neoplasms
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4534351 BXGD023218 Major psychiatric illness
C4551548 BXGD023342 Grade III Childhood Astrocytoma Neoplasms
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4553962 BXGD023553 Hyperkeratosis, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein