Showing entry for Major prion protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023738
Protein NameMajor prion protein
Uniport IdP04925
GenePrnp
Gene Id19122
DomainPrion; Prion_bPrPp
Pfam PF00377   PF11587  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032147 activation of protein kinase activity
Biological Process GO:0035584 calcium-mediated signaling using intracellular calcium source
Biological Process GO:0006878 cellular copper ion homeostasis
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0071280 cellular response to copper ion
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0007611 learning or memory
Biological Process GO:0090647 modulation of age-related behavioral decline
Biological Process GO:0046007 negative regulation of activated T cell proliferation
Biological Process GO:1902430 negative regulation of amyloid-beta formation
Biological Process GO:1902992 negative regulation of amyloid precursor protein catabolic process
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
Biological Process GO:0043086 negative regulation of catalytic activity
Biological Process GO:1902951 negative regulation of dendritic spine maintenance
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:0032689 negative regulation of interferon-gamma production
Biological Process GO:0032700 negative regulation of interleukin-17 production
Biological Process GO:0032703 negative regulation of interleukin-2 production
Biological Process GO:1900272 negative regulation of long-term synaptic potentiation
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0050860 negative regulation of T cell receptor signaling pathway
Biological Process GO:1990535 neuron projection maintenance
Biological Process GO:0006139 nucleobase-containing compound metabolic process
Biological Process GO:0010942 positive regulation of cell death
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:1901216 positive regulation of neuron death
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0090314 positive regulation of protein targeting to membrane
Biological Process GO:0061098 positive regulation of protein tyrosine kinase activity
Biological Process GO:0031648 protein destabilization
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:1905664 regulation of calcium ion import across plasma membrane
Biological Process GO:1900449 regulation of glutamate receptor signaling pathway
Biological Process GO:1902938 regulation of intracellular calcium activated chloride channel activity
Biological Process GO:0050730 regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:1901379 regulation of potassium ion transmembrane transport
Biological Process GO:0032880 regulation of protein localization
Biological Process GO:1904645 response to amyloid-beta
Biological Process GO:0046686 response to cadmium ion
Biological Process GO:0046688 response to copper ion
Biological Process GO:0006979 response to oxidative stress
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0019828 aspartic-type endopeptidase inhibitor activity
molecular function GO:0043008 ATP-dependent protein binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0051087 chaperone binding
molecular function GO:0005507 copper ion binding
molecular function GO:1903135 cupric ion binding
molecular function GO:1903136 cuprous ion binding
molecular function GO:0005539 glycosaminoglycan binding
molecular function GO:0042802 identical protein binding
molecular function GO:0044325 ion channel binding
molecular function GO:0005521 lamin binding
molecular function GO:0008017 microtubule binding
molecular function GO:0002020 protease binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0038023 signaling receptor activity
molecular function GO:0015631 tubulin binding
molecular function GO:0031802 type 5 metabotropic glutamate receptor binding
cellular component GO:0031225 anchored component of membrane
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016234 inclusion body
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0031965 nuclear membrane
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0043195 terminal bouton
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein