Showing entry for Neutrophil defensin 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023897
Protein NameNeutrophil defensin 4
Uniport IdP12838
GeneDEFA4
Gene Id1669
DomainDefensin_1; Defensin_propep
Pfam PF00323   PF00879  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019731 antibacterial humoral response
Biological Process GO:0019732 antifungal humoral response
Biological Process GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process GO:0019730 antimicrobial humoral response
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0050832 defense response to fungus
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0045087 innate immune response
Biological Process GO:0002227 innate immune response in mucosa
Biological Process GO:0031640 killing of cells of other organism
Biological Process GO:0051673 membrane disruption in other organism
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0010818 T cell chemotaxis
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0042582 azurophil granule
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005796 Golgi lumen
cellular component GO:0035580 specific granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-1461973 Defensins
R-HSA-1462054 Alpha-defensins
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6798695 Neutrophil degranulation
R-HSA-6803157 Antimicrobial peptides
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0025303 BXGD001858 Meningococcal Infections Infections
C0026277 BXGD001899 Mixed Salivary Gland Tumor Neoplasms
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C2347126 BXGD017036 Microscopic Polyarteritis Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein