Showing entry for Mothers against decapentaplegic homolog 9


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT024049
Protein NameMothers against decapentaplegic homolog 9
Uniport IdO15198
GeneSMAD9
Gene Id4093
DomainMH1; MH2
Pfam PF03165   PF03166  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04350 TGF-beta signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0071773 cellular response to BMP stimulus
Biological Process GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
Biological Process GO:0060395 SMAD protein signal transduction
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0046872 metal ion binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0071141 SMAD protein complex
cellular component GO:0005667 transcription regulator complex
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-201451 Signaling by BMP
R-HSA-9006936 Signaling by TGFB family members
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0005890 BXGD000345 Body Height
C0005938 BXGD000351 Bone Density
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0032584 BXGD002363 polyps Pathological Conditions, Signs and Symptoms
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0152171 BXGD003552 Idiopathic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0282193 BXGD006798 Iron Overload Nutritional and Metabolic Diseases
C0340543 BXGD007344 Familial primary pulmonary hypertension Respiratory Tract Diseases
C0346629 BXGD007831 Malignant neoplasm of large intestine Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C1150929 BXGD011768 2-oxo-hept-3-ene-1,7-dioate hydratase activity
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1701938 BXGD013524 Associated Pulmonary Arterial Hypertension Respiratory Tract Diseases
C1701939 BXGD013525 Familial pulmonary arterial hypertension
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1837315 BXGD014218 COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
C1867423 BXGD016452 Increased pulmonary vascular resistance
C1969342 BXGD016771 PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED Respiratory Tract Diseases
C1969343 BXGD016772 Pulmonary Hypertension, Primary, Fenfluramine-Associated Respiratory Tract Diseases
C2675481 BXGD017292 COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
C2677123 BXGD017364 COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3272802 BXGD018631 Hamartomatous polyposis Pathological Conditions, Signs and Symptoms; Neoplasms
C3554460 BXGD019215 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
C3697119 BXGD019352 Pulmonary arterial hypertension associated with congenital heart disease
C3714844 BXGD019435 Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia Respiratory Tract Diseases
C3888002 BXGD019939 PULMONARY HYPERTENSION, PRIMARY, 2
C4303092 BXGD022550 Cystic echinococcosis Pathological Conditions, Signs and Symptoms; Neoplasms; Infections
C4552070 BXGD023481 Pulmonary Hypertension, Primary, 1 Respiratory Tract Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein