Showing entry for Roundabout homolog 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT024280
Protein NameRoundabout homolog 2
Uniport IdQ9HCK4
GeneROBO2
Gene Id6092
Domainfn3; I-set; Ig_3
Pfam PF00041   PF07679  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0035904 aorta development
Biological Process GO:0003180 aortic valve morphogenesis
Biological Process GO:0061364 apoptotic process involved in luteolysis
Biological Process GO:0007411 axon guidance
Biological Process GO:0016199 axon midline choice point recognition
Biological Process GO:0007420 brain development
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:0007417 central nervous system development
Biological Process GO:0003272 endocardial cushion formation
Biological Process GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Biological Process GO:0001656 metanephros development
Biological Process GO:0050925 negative regulation of negative chemotaxis
Biological Process GO:0051964 negative regulation of synapse assembly
Biological Process GO:0021891 olfactory bulb interneuron development
Biological Process GO:0003148 outflow tract septum morphogenesis
Biological Process GO:0050772 positive regulation of axonogenesis
Biological Process GO:0035481 positive regulation of Notch signaling pathway involved in heart induction
Biological Process GO:0003184 pulmonary valve morphogenesis
Biological Process GO:0031290 retinal ganglion cell axon guidance
Biological Process GO:0021510 spinal cord development
Biological Process GO:0001657 ureteric bud development
Biological Process GO:0060412 ventricular septum morphogenesis
molecular function GO:0008046 axon guidance receptor activity
molecular function GO:0042802 identical protein binding
cellular component GO:0030673 axolemma
cellular component GO:0009986 cell surface
cellular component GO:0070062 extracellular exosome
cellular component GO:0016021 integral component of membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-376176 Signaling by ROBO receptors
R-HSA-376176 Signaling by ROBO receptors
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-HSA-8985801 Regulation of cortical dendrite branching
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9010642 ROBO receptors bind AKAP5
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003431 BXGD000190 Antisocial Personality Disorder Mental Disorders
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0008810 BXGD000572 Circadian Rhythms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0015644 BXGD001008 Muscular fasciculation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0022679 BXGD001575 Cystic kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023897 BXGD001719 Liver Diseases, Parasitic Digestive System Diseases; Infections
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0042580 BXGD002992 Vesico-Ureteral Reflux Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0149654 BXGD003343 Conduct Disorder Mental Disorders
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221365 BXGD004452 Double ureter
C0265219 BXGD005468 Miller Dieker syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266295 BXGD005645 Congenital hypoplasia of kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334054 BXGD006984 cystic disease
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0403622 BXGD008299 Primary vesicoureteric reflux Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0406775 BXGD008371 Symmetrical dyschromatosis of extremities Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0424296 BXGD008525 Social disinhibition Mental Disorders
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1305855 BXGD012348 Body mass index
C1611743 BXGD013456 Familial (FPAH)
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1858565 BXGD015807 Duplicated collecting system
C1968949 BXGD016744 Cakut Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1970483 BXGD016840 Vesicoureteral Reflux 2 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2697764 BXGD017434 Interleukin 16 Measurement
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3805278 BXGD019474 Extrahepatic Cholangiocarcinoma Neoplasms
C4021821 BXGD020806 Abnormality of the urinary system Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4551858 BXGD023425 Vesicoureteral Reflux 1 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4706552 BXGD023701 Familial vesicoureteral reflux
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein