Showing entry for Guanylate cyclase soluble subunit beta-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT024538
Protein NameGuanylate cyclase soluble subunit beta-1
Uniport IdQ02153
GeneGUCY1B1
Gene Id2983
DomainGuanylate_cyc; HNOB; HNOBA
Pfam PF00211   PF07700   PF07701  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008015 blood circulation
Biological Process GO:0071732 cellular response to nitric oxide
Biological Process GO:0006182 cGMP biosynthetic process
Biological Process GO:0019934 cGMP-mediated signaling
Biological Process GO:0038060 nitric oxide-cGMP-mediated signaling pathway
Biological Process GO:0007263 nitric oxide mediated signal transduction
Biological Process GO:0099555 trans-synaptic signaling by nitric oxide, modulating synaptic transmission
molecular function GO:0005525 GTP binding
molecular function GO:0004383 guanylate cyclase activity
molecular function GO:0020037 heme binding
molecular function GO:0046872 metal ion binding
molecular function GO:0038023 signaling receptor activity
cellular component GO:0008074 guanylate cyclase complex, soluble
cellular component GO:0048786 presynaptic active zone
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-392154 Nitric oxide stimulates guanylate cyclase
R-HSA-397014 Muscle contraction
R-HSA-418346 Platelet homeostasis
R-HSA-445355 Smooth Muscle Contraction
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0346156 BXGD007783 Benign neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0428886 BXGD008640 Mean blood pressure
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0871470 BXGD011316 Systolic Pressure
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0008676 Haem 616.49
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein