Showing entry for Nucleolar RNA helicase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT024748
Protein NameNucleolar RNA helicase 2
Uniport IdQ9NR30
GeneDDX21
Gene Id9188
DomainDEAD; GUCT; Helicase_C
Pfam PF00270   PF08152   PF00271  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051607 defense response to virus
Biological Process GO:0045087 innate immune response
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0045815 positive regulation of gene expression, epigenetic
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0002735 positive regulation of myeloid dendritic cell cytokine production
Biological Process GO:0043330 response to exogenous dsRNA
Biological Process GO:0062176 R-loop disassembly
Biological Process GO:0006364 rRNA processing
Biological Process GO:0006366 transcription by RNA polymerase II
molecular function GO:0097322 7SK snRNA binding
molecular function GO:0005524 ATP binding
molecular function GO:0003725 double-stranded RNA binding
molecular function GO:0042802 identical protein binding
molecular function GO:0035198 miRNA binding
molecular function GO:0003723 RNA binding
molecular function GO:0003724 RNA helicase activity
molecular function GO:0019843 rRNA binding
molecular function GO:0030515 snoRNA binding
cellular component GO:0005829 cytosol
cellular component GO:0016020 membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72312 rRNA processing
R-HSA-74160 Gene expression (Transcription)
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009782 BXGD000631 Connective Tissue Diseases Skin and Connective Tissue Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0242387 BXGD005161 Mandibulofacial Dysostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases
C0267211 BXGD005737 Gastric Antral Vascular Ectasia Digestive System Diseases; Cardiovascular Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C1260899 BXGD011841 Anemia, Diamond-Blackfan Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0024261 Adenosine Phosphate 347.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein