protein

Showing entry for Insulin-like growth factor 2 mRNA-binding protein 2

General Target Information
BXGT Id	BXGT025468
Protein Name	Insulin-like growth factor 2 mRNA-binding protein 2
Uniport Id	Q9Y6M1
Gene	IGF2BP2
Gene Id	10644
Domain	KH_1; RRM_1
Pfam	PF00013 PF00076
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0009653	anatomical structure morphogenesis
Biological Process	GO:0051028	mRNA transport
Biological Process	GO:0017148	negative regulation of translation
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0042035	regulation of cytokine biosynthetic process
Biological Process	GO:0010468	regulation of gene expression
Biological Process	GO:0043488	regulation of mRNA stability
Biological Process	GO:0051252	regulation of RNA metabolic process
molecular function	GO:0003730	mRNA 3'-UTR binding
molecular function	GO:0048027	mRNA 5'-UTR binding
molecular function	GO:0003729	mRNA binding
molecular function	GO:0003723	RNA binding
molecular function	GO:0045182	translation regulator activity
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005856	cytoskeleton
cellular component	GO:0005829	cytosol
cellular component	GO:0005634	nucleus

Reactome

Pathway Id	Pathway Name
R-HSA-428359	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
R-HSA-8953854	Metabolism of RNA

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001430	BXGD000054	Adenoma	Neoplasms
C0005890	BXGD000345	Body Height
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007097	BXGD000424	Carcinoma	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0007222	BXGD000454	Cardiovascular Diseases	Cardiovascular Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0010068	BXGD000648	Coronary heart disease	Cardiovascular Diseases
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881	BXGD000760	Diabetic Nephropathy	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013537	BXGD000853	Eclampsia	Female Urogenital Diseases and Pregnancy Complications
C0015695	BXGD001013	Fatty Liver	Digestive System Diseases
C0016529	BXGD001068	Forced expiratory volume function
C0017636	BXGD001131	Glioblastoma	Neoplasms
C0017638	BXGD001132	Glioma	Neoplasms
C0020456	BXGD001392	Hyperglycemia	Nutritional and Metabolic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0021655	BXGD001508	Insulin Resistance	Nutritional and Metabolic Diseases
C0021704	BXGD001510	Intelligence	Behavior and Behavior Mechanisms
C0023418	BXGD001642	leukemia	Neoplasms
C0023449	BXGD001650	Acute lymphocytic leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452	BXGD001651	Childhood Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467	BXGD001658	Leukemia, Myelocytic, Acute	Neoplasms
C0023827	BXGD001707	liposarcoma	Neoplasms
C0023890	BXGD001713	Liver Cirrhosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024299	BXGD001758	Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030297	BXGD002204	Pancreatic Neoplasm	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0032181	BXGD002332	Platelet Count measurement
C0032460	BXGD002355	Polycystic Ovary Syndrome	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0037579	BXGD002694	Soft Tissue Neoplasms	Neoplasms
C0042834	BXGD003004	Vital capacity
C0085207	BXGD003140	Gestational Diabetes	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0158850	BXGD003910	Fetal Malnutrition	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0202230	BXGD004084	Thyroid stimulating hormone measurement
C0205682	BXGD004105	Waist-Hip Ratio
C0206687	BXGD004242	Carcinoma, Endometrioid	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0221765	BXGD004477	Chronic schizophrenia	Mental Disorders
C0235782	BXGD004769	Gallbladder Carcinoma	Digestive System Diseases; Neoplasms
C0235974	BXGD004796	Pancreatic carcinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0268398	BXGD005933	Familial lichen amyloidosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0271650	BXGD006227	Impaired glucose tolerance	Nutritional and Metabolic Diseases
C0278498	BXGD006521	Malignant neoplasm of stomach stage IV
C0278878	BXGD006609	Adult Glioblastoma	Neoplasms
C0278996	BXGD006621	Malignant Head and Neck Neoplasm	Neoplasms
C0280474	BXGD006748	Childhood Glioblastoma	Neoplasms
C0337438	BXGD007159	Glucose measurement
C0346647	BXGD007832	Malignant neoplasm of pancreas	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0362046	BXGD007959	Prediabetes syndrome	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0427460	BXGD008616	Red cell distribution width determination
C0428568	BXGD008633	Fasting blood glucose measurement
C0495706	BXGD009038	elevated blood glucose level
C0524620	BXGD009236	Metabolic Syndrome X	Nutritional and Metabolic Diseases
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0751606	BXGD010523	Adult Acute Lymphocytic Leukemia
C0752304	BXGD010711	Hypoxic-Ischemic Encephalopathy	Nervous System Diseases; Cardiovascular Diseases
C0919267	BXGD011426	ovarian neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680	BXGD011718	Malignant neoplasm of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261430	BXGD011853	Fasting blood sugar result
C1266089	BXGD011954	Metaplastic carcinoma	Neoplasms
C1269955	BXGD012005	Tumor Cell Invasion
C1301034	BXGD012282	Pancreatic intraepithelial neoplasia	Neoplasms
C1304746	BXGD012343	RDW - Red blood cell distribution width result
C1305855	BXGD012348	Body mass index
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1332977	BXGD012569	Childhood Leukemia	Neoplasms
C1335302	BXGD012775	Pancreatic Ductal Adenocarcinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1512409	BXGD013188	Hepatocarcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C1514422	BXGD013202	Glioblastoma, IDH-Wildtype	Neoplasms
C1518922	BXGD013229	peak expiratory flow (procedure)
C1621958	BXGD013468	Glioblastoma Multiforme	Neoplasms
C1623038	BXGD013475	Cirrhosis	Pathological Conditions, Signs and Symptoms
C1832661	BXGD013866	ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2711227	BXGD017478	Steatohepatitis	Digestive System Diseases
C3539878	BXGD019087	Triple Negative Breast Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C3887461	BXGD019876	Head and Neck Carcinoma	Neoplasms
C4703555	BXGD023658	Decreased waist to hip ratio
C4721610	BXGD023760	Carcinoma, Ovarian Epithelial	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum
C4722518	BXGD023806	Triple-Negative Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000436	Glycerol		92.09

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}