Showing entry for Interleukin-12 subunit beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025561
Protein NameInterleukin-12 subunit beta
Uniport IdP43432
GeneIl12b
Gene Id16160
DomainIL12p40_C
Pfam PF10420  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0016477 cell migration
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0071346 cellular response to interferon-gamma
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0042832 defense response to protozoan
Biological Process GO:0051607 defense response to virus
Biological Process GO:0030101 natural killer cell activation
Biological Process GO:0002323 natural killer cell activation involved in immune response
Biological Process GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Biological Process GO:0002862 negative regulation of inflammatory response to antigenic stimulus
Biological Process GO:0032693 negative regulation of interleukin-10 production
Biological Process GO:0032700 negative regulation of interleukin-17 production
Biological Process GO:0050709 negative regulation of protein secretion
Biological Process GO:0048662 negative regulation of smooth muscle cell proliferation
Biological Process GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
Biological Process GO:0042104 positive regulation of activated T cell proliferation
Biological Process GO:0010536 positive regulation of activation of Janus kinase activity
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:0002230 positive regulation of defense response to virus by host
Biological Process GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
Biological Process GO:0032729 positive regulation of interferon-gamma production
Biological Process GO:0032733 positive regulation of interleukin-10 production
Biological Process GO:0032735 positive regulation of interleukin-12 production
Biological Process GO:0032740 positive regulation of interleukin-17 production
Biological Process GO:0050671 positive regulation of lymphocyte proliferation
Biological Process GO:0032946 positive regulation of mononuclear cell proliferation
Biological Process GO:0032816 positive regulation of natural killer cell activation
Biological Process GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
Biological Process GO:0032819 positive regulation of natural killer cell proliferation
Biological Process GO:0051135 positive regulation of NK T cell activation
Biological Process GO:0051142 positive regulation of NK T cell proliferation
Biological Process GO:0045672 positive regulation of osteoclast differentiation
Biological Process GO:0034393 positive regulation of smooth muscle cell apoptotic process
Biological Process GO:0001916 positive regulation of T cell mediated cytotoxicity
Biological Process GO:0042102 positive regulation of T cell proliferation
Biological Process GO:0002827 positive regulation of T-helper 1 type immune response
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
Biological Process GO:0042509 regulation of tyrosine phosphorylation of STAT protein
Biological Process GO:0010033 response to organic substance
Biological Process GO:0010224 response to UV-B
Biological Process GO:0019233 sensory perception of pain
Biological Process GO:0035744 T-helper 1 cell cytokine production
Biological Process GO:0042093 T-helper cell differentiation
molecular function GO:0005125 cytokine activity
molecular function GO:0019955 cytokine binding
molecular function GO:0004896 cytokine receptor activity
molecular function GO:0008083 growth factor activity
molecular function GO:0042802 identical protein binding
molecular function GO:0042164 interleukin-12 alpha subunit binding
molecular function GO:0045519 interleukin-23 receptor binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0046982 protein heterodimerization activity
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0031904 endosome lumen
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005796 Golgi lumen
cellular component GO:0043514 interleukin-12 complex
cellular component GO:0070743 interleukin-23 complex
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein