Showing entry for Iron-sulfur cluster assembly enzyme ISCU, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025766
Protein NameIron-sulfur cluster assembly enzyme ISCU, mitochondrial
Uniport IdQ9H1K1
GeneISCU
Gene Id23479
DomainNifU_N
Pfam PF01592  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006879 cellular iron ion homeostasis
Biological Process GO:0016226 iron-sulfur cluster assembly
Biological Process GO:1904439 negative regulation of iron ion import across plasma membrane
Biological Process GO:1904234 positive regulation of aconitate hydratase activity
Biological Process GO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone
Biological Process GO:0044281 small molecule metabolic process
molecular function GO:0051537 2 iron, 2 sulfur cluster binding
molecular function GO:0051539 4 iron, 4 sulfur cluster binding
molecular function GO:0008198 ferrous iron binding
molecular function GO:0005506 iron ion binding
molecular function GO:0060090 molecular adaptor activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001125 BXGD000024 Acidosis, Lactic Nutritional and Metabolic Diseases
C0002896 BXGD000153 Sideroblastic anemia Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016719 BXGD001074 Friedreich Ataxia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019623 BXGD001341 Malignant histiocytosis Neoplasms; Hemic and Lymphatic Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027080 BXGD001969 Myoglobinuria Musculoskeletal Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0030421 BXGD002218 Paraganglioma Neoplasms
C0033626 BXGD002412 Protein Deficiency Nutritional and Metabolic Diseases
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079774 BXGD003101 Peripheral T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0162670 BXGD003970 Mitochondrial Myopathies Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0279650 BXGD006673 Childhood Acute Megakaryoblastic Leukemia Neoplasms
C0282193 BXGD006798 Iron Overload Nutritional and Metabolic Diseases
C0394005 BXGD008165 Ataxic cerebral palsy Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0424551 BXGD008533 Impaired exercise tolerance
C0431129 BXGD008665 Adamantinous Craniopharyngioma Neoplasms
C0456889 BXGD008881 Enteropathy-Associated T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1836440 BXGD014115 Increased serum lactate Nutritional and Metabolic Diseases
C1850718 BXGD015171 MYOPATHY WITH EXERCISE INTOLERANCE, SWEDISH TYPE Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C1856689 BXGD015630 FRIEDREICH ATAXIA 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2677650 BXGD017382 Decreased activity of mitochondrial complex I
C3149083 BXGD018274 Decreased activity of mitochondrial complex III
C3151556 BXGD018442 Abnormal iron deposition in mitochondria
C3160712 BXGD018467 Palpitations, CTCAE
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C4020730 BXGD020473 Increased intramyocellular lipid droplets
C4024705 BXGD021378 Decreased activity of mitochondrial complex II
C4025597 BXGD021685 Subsarcolemmal accumulations of abnormally shaped mitochondria
C4721452 BXGD023743 Intestinal T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein